Intravascular large B-cell lymphoma presenting as panniculitis

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Presentation transcript:

Intravascular large B-cell lymphoma presenting as panniculitis Corinne Maiolo, MBBS, S. Jan Ibbetson, MBBS, FRCPA, Shireen K. Sidhu, MBBS, FRCP, FACD, Daniel Kearney, MBBS, FRCPA JAAD Case Reports Volume 3, Issue 6, Pages 536-538 (November 2017) DOI: 10.1016/j.jdcr.2017.06.032 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Intravascular B cell lymphoma. Subcutaneous nodules in the left inframammary region with overlying retiform purpura and extension across the abdomen. JAAD Case Reports 2017 3, 536-538DOI: (10.1016/j.jdcr.2017.06.032) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Scant mixed inflammatory cell infiltrate in fat lobules, comprising neutrophils and a few eosinophils, with vascular congestion with extensive fat necrosis and ghost outlines of fat cells. (Original magnification: ×200.) JAAD Case Reports 2017 3, 536-538DOI: (10.1016/j.jdcr.2017.06.032) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Intravascular B cell lymphoma. A vessel shows occlusion by a proliferation of intermediate-sized cells with scant cytoplasm and hyperchromatic and irregular nuclei. (Original magnification: ×400.) JAAD Case Reports 2017 3, 536-538DOI: (10.1016/j.jdcr.2017.06.032) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Strong CD20 positivity with weak co-expression of CD5 and a very high proliferation rate, indicating a B-cell intravascular lymphoma. (Original magnification: ×400.) JAAD Case Reports 2017 3, 536-538DOI: (10.1016/j.jdcr.2017.06.032) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions