Effects of follicle-stimulating hormone and human chorionic gonadotropin on gonadal steroidogenesis in two siblings with a follicle-stimulating hormone.

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Presentation transcript:

Effects of follicle-stimulating hormone and human chorionic gonadotropin on gonadal steroidogenesis in two siblings with a follicle-stimulating hormone β subunit mutation Adriana Lofrano-Porto, M.D., Luiz Augusto Casulari, M.D., Paula P. Nascimento, Leonardo Giacomini, Luciana A. Naves, M.D., Lucilia Domingues Casulari da Motta, M.D., Lawrence C. Layman, M.D. Fertility and Sterility Volume 90, Issue 4, Pages 1169-1174 (October 2008) DOI: 10.1016/j.fertnstert.2007.07.1356 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Schematic representation of the endocrine evaluation protocol. Serial samples of LH were drawn overnight. After dexamethasone suppression for 2 days, serum steroids were measured at baseline and repeated after hCG administration, and, 1 month later, after hCG + recombinant FSH administration. Gonadotropin administration = long arrows; blood samples collections for steroid data = short arrows. Adapted from Barnes et al. (7). Fertility and Sterility 2008 90, 1169-1174DOI: (10.1016/j.fertnstert.2007.07.1356) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions