Dose responsive suppression of myointimal hyperplasia by dexamethasone

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Presentation transcript:

Dose responsive suppression of myointimal hyperplasia by dexamethasone Michael D. Colburn, MD, Wesley S. Moore, MD, Hugh A. Gelabert, MD, William J. Quiñones-Baldrich, MD Journal of Vascular Surgery Volume 15, Issue 3, Pages 510-518 (March 1992) DOI: 10.1016/0741-5214(92)90190-J Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Chart shows effect of graded doses of dexamethasone on IH/IEL index. Journal of Vascular Surgery 1992 15, 510-518DOI: (10.1016/0741-5214(92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Chart shows effect of graded doses of dexamethasone on measured blood flow. Journal of Vascular Surgery 1992 15, 510-518DOI: (10.1016/0741-5214(92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Chart shows effect of graded doses of dexamethasone on calculated value ΔP/flow. Journal of Vascular Surgery 1992 15, 510-518DOI: (10.1016/0741-5214(92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 4 Photomicrograph of control artery shows high degree of intimal hyperplasia (Verhoeff van Geison's stain; original magnification × 20). Journal of Vascular Surgery 1992 15, 510-518DOI: (10.1016/0741-5214(92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 5 Photomicrograph of artery treated for 8 weeks with dexamethasone 0.050 mg/kg shows some reduction in degree of intimal hyperplasia (Verhoeff van Geison's stain; original magnification × 20). Journal of Vascular Surgery 1992 15, 510-518DOI: (10.1016/0741-5214(92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 6 Absence of significant intimal hyperplasia in photomicrograph of artery treated for 8 weeks with dexamethasone 0.125 mg/kg (Verhoeff van Geison's stain; original magnification × 20). Journal of Vascular Surgery 1992 15, 510-518DOI: (10.1016/0741-5214(92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions