Volume 12, Issue 2, Pages 139-140 (February 2013) The Young and the Restless: Regulation of Adult Neurogenesis by Wnt Signaling  Melody V. Wu, René Hen  Cell Stem Cell  Volume 12, Issue 2, Pages 139-140 (February 2013) DOI: 10.1016/j.stem.2013.01.013 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Wnt Antagonists Inhibit Adult Hippocampal Neurogenesis Wnt protein binding of the Frizzled/LRP heteromeric receptor and downstream formation of the β-catenin TCF/LEF complex leads to subsequent transcriptional activation of target genes. Inhibition by Dickkopf 1 (Dkk1) and secreted frizzled-related protein 3 (sFRP3) of Wnt signaling downregulates adult stem cell proliferation and neuronal maturation. Exercise or electroshock (ECS)-mediated neuronal activity inhibits sFRP3 expression, allowing Wnt-Frizzled/LRP binding and activating adult radial glial-like stem cells. Conversely, Dkk1 expression increases with age, precluding formation of the Wnt receptor complex and leading to suppression of adult hippocampal neurogenesis. Cell Stem Cell 2013 12, 139-140DOI: (10.1016/j.stem.2013.01.013) Copyright © 2013 Elsevier Inc. Terms and Conditions