Nucleosomes and Cisplatin

Slides:

Advertisements

Similar presentations

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB Sonja Baumli, Jane A. Endicott, Louise N. Johnson Chemistry & Biology Volume 17, Issue.

Advertisements

Binocular rivalry Colin W.G. Clifford Current Biology Volume 19, Issue 22, Pages R1022-R1023 (December 2009) DOI: /j.cub Copyright ©

Development of Antibiotic Activity Profile Screening for the Classification and Discovery of Natural Product Antibiotics Weng Ruh Wong, Allen G. Oliver,

Regulation of Telomere Length by G-Quadruplex Telomere DNA- and TERRA-Binding Protein TLS/FUS Kentaro Takahama, Asami Takada, Shota Tada, Mai Shimizu,

Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &

Nitric Oxide-Mediated Histone Hyperacetylation in Oral Cancer: Target for a Water- Soluble HAT Inhibitor, CTK7A Mohammed Arif, Bhusainahalli M. Vedamurthy,

Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages (April 2010) DOI: /j.tics

In Vivo Photoswitchable Flow Cytometry for Direct Tracking of Single Circulating Tumor Cells Dmitry A. Nedosekin, Vladislav V. Verkhusha, Alexander V.

A Fluorescent Hydrogel-Based Flow Cytometry High-Throughput Screening Platform for Hydrolytic Enzymes Christian Pitzler, Georgette Wirtz, Ljubica Vojcic,

A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi.

Biocompatible Quantum Dots for Biological Applications Sandra J. Rosenthal, Jerry C. Chang, Oleg Kovtun, James R. McBride, Ian D. Tomlinson Chemistry &

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates Bradley Croy Doak, Bj ӧ rn Over, Fabrizio Giordanetto, Jan Kihlberg.

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs Yves Pommier, Elisabetta Leo, HongLiang Zhang, Christophe Marchand Chemistry.

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Alexei F. Kisselev, Wouter A. van der Linden, Herman S. Overkleeft Chemistry & Biology.

Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria Alban Pereira, Zhengyu Cao, Thomas.

Context-Specific Target Definition in Influenza A Virus Hemagglutinin-Glycan Receptor Interactions Zachary Shriver, Rahul Raman, Karthik Viswanathan, Ram.

Staphylococcus aureus and Bacillus subtilis W23 Make Polyribitol Wall Teichoic Acids Using Different Enzymatic Pathways Stephanie Brown, Timothy Meredith,

The Efficacy of siRNAs against Hepatitis C Virus Is Strongly Influenced by Structure and Target Site Accessibility Selena M. Sagan, Neda Nasheri, Christian.

Cationic Fullerenes Are Effective and Selective Antimicrobial Photosensitizers George P. Tegos, Tatiana N. Demidova, Dennisse Arcila-Lopez, Haeryeon Lee,

How surgeons can find information online? Martin Hewitt International Journal of Surgery Volume 5, Issue 6, Pages (December 2007) DOI: /j.ijsu

The Origins and Evolution of Vertebrate Metamorphosis Vincent Laudet Current Biology Volume 21, Issue 18, Pages R726-R737 (September 2011) DOI: /j.cub

Glycosidase Inhibition by Macrolide Antibiotics Elucidated by STD-NMR Spectroscopy Ali Sadeghi-Khomami, Michael D. Lumsden, David L. Jakeman Chemistry.

Thank God for Richard Dawkins?

Nucleosomes and Cisplatin

An Unnatural PIP Simulates Growth Factor Signaling

Volume 22, Issue 5, Pages v-vi (May 2015)

Now Playing: Farnesol in the Biofilm

DNMT1 and Cancer: An Electrifying Link

Tailor-Made Peptide Synthetases

On-Bead Library Screening Made Easier

Antibiotics: A New Hope

Foundations for Directed Alkaloid Biosynthesis

Nature’s Strategy for Catalyzing Diels-Alder Reaction

Chemical Proteomics of Host-Pathogen Interaction

In Search of the Missing Ligands for TetR Family Regulators

Visual Development: Learning Not to See

Adding Specificity to Artificial Transcription Activators

Finding the Missing Code of RNA Recognition by PUF Proteins

Tuberculosis Terpene Targets

News in Ubiquinone Biosynthesis

Tandem Modifications of an Epoxyquinone C7N Pharmacophore

Reassembling Biological Machinery In Vitro

Activity-Based Profiling of 2-Oxoglutarate Oxygenases

Targeting the Undruggable Proteome: The Small Molecules of My Dreams

Reassembling Biological Machinery In Vitro

A Noncanonical Path to Mechanism of Action

Bioactive Cell-Penetrating Peptides: Kill Two Birds with One Stone

Volume 362, Pages s6-s7 (December 2003)

Jekyll & Hyde: Evolution of a Superfamily

No Need To Be Pure: Mix the Cultures!

Resolving Resolvins Chemistry & Biology

Now Playing: Farnesol in the Biofilm

BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons

Thank God for Richard Dawkins?

Volume 21, Issue 8, Pages v-vi (August 2014)

Foundations for Directed Alkaloid Biosynthesis

Discrimination between Two Endocannabinoids

Visual Development: Learning Not to See

Bivalent Aptamers Deliver the Punch

Redesigning the Architecture of the Base Pair: Toward Biochemical and Biological Function of New Genetic Sets Andrew T. Krueger, Eric T. Kool Chemistry.

Nature’s Strategy for Catalyzing Diels-Alder Reaction

L-DOPA Ropes in tRNAPhe

Volume 7, Issue 6, Pages R147-R151 (June 2000)

Volume 21, Issue 9, Pages (September 2014)

Self-Assembling, Dynamic αPNAs

Tools to Tackle Protein Acetylation

Volume 21, Issue 9, Pages (September 2014)

Volume 18, Issue 5, Pages R198-R202 (March 2008)

Volume 22, Issue 4, Pages vii-viii (April 2015)

Presentation transcript:

Nucleosomes and Cisplatin Vincent Murray Chemistry & Biology Volume 17, Issue 12, Pages 1271-1272 (December 2010) DOI: 10.1016/j.chembiol.2010.12.002 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Two Procedures for Investigation of the Interaction of Cisplatin with Nucleosomal DNA (A) Cisplatin adducts are formed on a defined DNA sequence, an octamer of histones is added, and a Pt-nucleosome complex is produced. (B) A nucleosome is constructed on a defined DNA sequence, the nucleosome is treated with cisplatin, and the Pt-DNA adducts are analyzed. Chemistry & Biology 2010 17, 1271-1272DOI: (10.1016/j.chembiol.2010.12.002) Copyright © 2010 Elsevier Ltd Terms and Conditions