Proportional change of enrolled patients in each geographical region between 2000 and 2006 MARCH 2008 SOURCE: CMR INTERNATIONAL PERFORMANCE METRICS PROGRAM © THOMSON REUTERS Your use of these materials is subject to the terms and conditions hereof. Please read the disclaimer carefully before using these materials.

Proportional change of enrolled patients in each geographical region between 2000 and 2006 Chapter 6 Regional comparisons Figure 6.4 Global patient enrolment 2000 vs 2006 Europe Core Europe Non-Core EU Accession 2006 14% 13% 7% 2000 21% 8% 4% ME & Africa 2% 2000 41% 2006 39% North America 2000 2% 2006 7% SE Asia & W Pacific Key message Comparing 2006 with the start of the decade, the proportion of patients enrolled in the 5 major European markets has declined by one third, with a modest decrease also observed in North America. The decline has been counterbalanced by increases in the number enrolled from the emerging markets and other European countries. Methodology This analysis compares the proportion of enrolled patients in each geographical region in 200 with 2006. Studies were included where enrolment was completed in the year ranges specified and patient data by region were available. Data from 23 companies providing data for all years. Key Definitions Europe Core countries: Includes France, Germany, Italy, Spain and UK. Europe: Includes the following 49 countries with the exception of Europe Core countries: i) All EU members states, ii) EEA members Iceland and Norway, iii) EU candidate countries Croatia, Former Yugoslav Republic of Macedonia, and Turkey, and iv) each of the following other European countries: Albania, Andorra, Armenia, Azerbaijan, Belarus, Bosnia and Herzegovina, Georgia, Liechtenstein, Moldova, Monaco, Montenegro, Russia, San Marino, Serbia, Switzerland, Ukraine and Vatican City State. EU accession: Includes, Cyprus, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Malta, Poland, Slovakia, Slovenia. Latin America: Includes, Argentina, Brazil, Chile, Colombia, Costa Rica, Dominican Republic, Ecuador, Guadeloupe, Guatemala, Honduras, Jamaica, Martinique, Mexico, Panama, Peru, Puerto Rico, Uruguay and Venezuela Middle East & Africa: Includes, Middle East & Africa includes the following countries: Afghanistan, Algeria, Bahrain, Egypt, Iran, Israel, Ivory Coast, Jordan, Kenya, Lebanon, Morocco, Namibia, Nigeria, Oman, Reunion, Saudi Arabia, South Africa, Tanzania, Tunisia, Turkey, United Arab Emirates North America: Includes USA and Canada SE Asia & W Pacific: Includes, Australia, Bangladesh, China, Hong Kong, India, Indonesia, Japan, Korea, Laos, Malaysia, New Zealand, Pakistan, Philippines, Singapore, Taiwan, Thailand, Vietnam CMR International Performance Metrics Program / Source Global Clinical Performance Metrics Program Latin America 2000 3% 2006 7% Based on studies from a consistent cohort of 23 companies where patient enrolment was completed in each year range. Percentages may not necessarily add up to 100% as some study locations may be unassigned. SOURCE: CMR INTERNATIONAL PERFORMANCE METRICS PROGRAM © THOMSON REUTERS

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