How I treat extramedullary acute myeloid leukemia

Slides:

Advertisements

Similar presentations

Lymphoma dissemination: the other face of lymphocyte homing by Steven T. Pals, David J. J. de Gorter, and Marcel Spaargaren Blood Volume 110(9):

Advertisements

CD11b is a therapy resistance– and minimal residual disease–specific marker in precursor B-cell acute lymphoblastic leukemia by Peter Rhein, Rita Mitlohner,

The angiogenesis inhibitor vasostatin is regulated by neutrophil elastase–dependent cleavage of calreticulin in AML patients by Sarah Mans, Yara Banz,

Kidney Involvement in Leukemia and Lymphoma

Tiffany Shao, Jordan Weinstein, Serge Jothy, Marc Goldstein

How I treat the antiphospholipid syndrome

Unilateral eyelid swelling, proptosis and diplopia as initial manifestation of acute myeloid leukemia Imtiaz A. Chaudhry, MD, PhD, FACS, Ahmad M. Alaraj,

Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification by Estella.

The beauty of TLR agonists for CTCL

How I treat LGL leukemia

NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case.

Flow cytometric immunophenotyping for hematologic neoplasms

Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo by Farideh Miraki-Moud, Essam.

by Udomsak Bunworasate, Hilal Arnouk, Hans Minderman, Kieran L

Dasatinib induces complete remission in a patient with primary cerebral involvement of B-cell chronic lymphocytic leukemia failing chemotherapy by Georg.

Anti-CD20 monoclonal antibody treatment in 6 patients with therapy-refractory chronic graft-versus-host disease by Marijke R. Canninga-van Dijk, Hanneke.

by Thomas S. Uldrick, and Richard F. Little

How I treat hairy cell leukemia

Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib Nobukazu Agatsuma, MD Journal of.

Rituximab-induced tumor cell agglutination

Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD by Kathrin Rieger, Christoph Loddenkemper, Jochem Maul, Thomas Fietz,

Leukemia initiated by PMLRARα: the PML domain plays a critical role while retinoic acid–mediated transactivation is dispensable by Scott C. Kogan, Suk-hyun.

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque by Ruth Seggewiss, Stefania Pittaluga,

CMV: when bad viruses turn good

Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia by Teresa Padró, Sandra Ruiz, Ralf Bieker, Horst Bürger, Martin Steins,

Volume 1, Issue 2, Pages (March 2015)

Significance of circulating T-cell clones in Sézary syndrome

Y.-H.H. Lien, K.-C. Yong, C. Cho, S. Igarashi, L.-W. Lai

by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle

Chronic lymphocytic leukemia and cryoglobulinemic glomerulonephritis

Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like.

WHO-EORTC classification for cutaneous lymphomas

Kidney Involvement in Leukemia and Lymphoma

A Strong Expression of CD44-6v Correlates With Shorter Survival of Patients With Acute Myeloid Leukemia by S. Legras, U. Günthert, R. Stauder, F. Curt,

Variability of PD-L1 expression in mastocytosis

Complete remission through blast cell differentiation inPLZF/RARα-positive acute promyelocytic leukemia: in vitro and in vivo studies by Maria C. Petti,

Justin J. Leitenberger, BS, Cindy N. Berthelot, MD, Kristel D

Cytokine-Release Syndrome in Patients With B-Cell Chronic Lymphocytic Leukemia and High Lymphocyte Counts After Treatment With an Anti-CD20 Monoclonal.

Caught in transformation

Evidence of a Graft-versus-Hodgkin Lymphoma Effect in the Setting of Extensive Bone Marrow Involvement Paolo Anderlini, MD Biology of Blood and Marrow.

Small Cell Transformation and T790M Mutation as Coresistance Mechanisms for First- line Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor.

Th17 immune microenvironment in Epstein-Barr virus–negative Hodgkin lymphoma: implications for immunotherapy by Amy S. Duffield, Maria Libera Ascierto,

Evolution of a chemosensitive core-binding factor AML into an aggressive leukemia with eosinophilic differentiation by Wenbin Xiao, Mariko Yabe, Michael.

Volume 1, Issue 4, Pages (July 2015)

Radiological and pathological findings in a common variable immunodeficiency patient with granulomatous-lymphocytic interstitial lung disease. a) High-resolution.

Immunoglobulin G4-Related Disease Presenting as an Obstructing Tracheal Mass: Consideration of Surgical Indications Edward M. Kobraei, MD, Tae H. Song,

Volume 3, Issue 6, Pages (November 2017)

Multimodality Therapy for Large Cell Neuroendocrine Carcinoma of the Thymus Naoko Ose, MD, Masayoshi Inoue, MD, Eiichi Morii, MD, Yasushi Shintani, MD,

by Geling Li, Emily Waite, and Julie Wolfson

Asymptomatic but Functional Paraganglioma of the Posterior Mediastinum

Control computed tomography of the nodular lesion in the right upper lobe after 3 months. a) Axial mediastinal window, b) axial lung window and c) coronal.

BCR-ABL1 gene rearrangement as a subclonal change in ETV6-RUNX1–positive B-cell acute lymphoblastic leukemia by Karen A. Dun, Rob Vanhaeften, Tracey J.

by Rupert Handgretinger, Peter Lang, and Maya C. André

T Cell Receptor-γ Gene Analysis of CD30+ Large Atypical Individual Cells in CD30+ Large Primary Cutaneous T Cell Lymphomas Sylke Gellrich, Anke Wilks,

HOXB6 overexpression results in delayed AML

Histological and immunohistochemical evaluation of primary central nervous system lymphoma. Histological and immunohistochemical evaluation of primary.

Molecular Therapy Volume 21, Pages S247-S248 (May 2013)

Tuberculous pseudoaneurysm of the femoral artery complicated by cutaneous tuberculosis of the foot: A case report Kathryn Leccese, BSc, José Ferreira,

Volume 58, Issue 5, Pages (November 2000)

Focal Cholesterol Granuloma in the Anterior Mediastinum: [18F]-Fluoro-2-Deoxy-D- Glucose-Positron Emission Tomography and Magnetic Resonance Imaging Findings

Effect of berberine on white adipose tissue mass.

Anticonvulsant-induced toxic epidermal necrolysis: Monitoring the immunologic response Laura Leyva, MD, PhDa, Maria José Torres, MD, PhDa, Sinforiano.

Sickle cells and sickle trait in thrombosis

Treatment of cutaneous pseudolymphoma with interferon alfa-2b

Systemic effects of local allergic disease

Extramedullary Plasmacytoma Arising From the Anterior Mediastinum

How I treat early-relapsing follicular lymphoma

Bone marrow fibrosis associated with long-term imatinib therapy: resolution after switching to a second-generation TKI by Naranie Shanmuganathan, Susan.

Myeloid neoplasms with eosinophilia

Skin punch biopsy from an upper back lesion showing extensive dermal neutrophilic infiltrate consistent with diagnosis of Sweet's syndrome. Skin punch.

Presentation transcript:

How I treat extramedullary acute myeloid leukemia by Richard L. Bakst, Martin S. Tallman, Dan Douer, and Joachim Yahalom Blood Volume 118(14):3785-3793 October 6, 2011 ©2011 by American Society of Hematology

Histologic appearance of EM leukemia. Histologic appearance of EM leukemia. (A) Hematoxylin and eosin staining of a MS along the right psoas muscle (original magnification ×40), demonstrating blasts in the skeletal muscle. Dense dermal infiltrate of monocytic leukemic cells (B; original magnification ×10; C: original magnification ×40), consistent with LC. Images were captured by the Olympus BX 41 microscope using an Olympus DP20 camera (Olympus) and imported directly as a series of .tif files. Richard L. Bakst et al. Blood 2011;118:3785-3793 ©2011 by American Society of Hematology

Immunophenotypic profile of EM myeloid leukemia. Immunophenotypic profile of EM myeloid leukemia. A panel of immunohistochemical markers may be useful in establishing the diagnosis of MS or LC. Myeloid (A) and monocytic (B) blast cells can express variable immunophenotypes, which may aid in their distinction. Richard L. Bakst et al. Blood 2011;118:3785-3793 ©2011 by American Society of Hematology

Radiographic appearance of MS Radiographic appearance of MS. MS along with the path of the right femoral nerve on (A) coronal computed tomography imaging, (B) coronal axial T1 postmagnetic resonance imaging, and (C) positron emission tomography. Radiographic appearance of MS. MS along with the path of the right femoral nerve on (A) coronal computed tomography imaging, (B) coronal axial T1 postmagnetic resonance imaging, and (C) positron emission tomography. Richard L. Bakst et al. Blood 2011;118:3785-3793 ©2011 by American Society of Hematology

Radiation therapy treatment field design and response. Radiation therapy treatment field design and response. (A) MS in the right pelvis on positron emission tomography. (B) Radiation field treated to 24 Gy. Positron emission tomography scan 2 months after radiation, demonstrating resolution of lesion. Richard L. Bakst et al. Blood 2011;118:3785-3793 ©2011 by American Society of Hematology

Leukemic cell surface markers implicated in EM homing. Leukemic cell surface markers implicated in EM homing. Blast cell CD56 (neural cell adhesion molecule) expression has been associated with both MS and LC. Homing of blast cells into the skin may be mediated through interactions between lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) and/or cutaneous leukocyte antigen (CLA) and E-selectin. Richard L. Bakst et al. Blood 2011;118:3785-3793 ©2011 by American Society of Hematology