Early presentation of de novo high grade glioma with epileptic seizures: electroclinical and neuroimaging findings Rosario Rossi, Andrea Figus, Simona.

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Early presentation of de novo high grade glioma with epileptic seizures: electroclinical and neuroimaging findings Rosario Rossi, Andrea Figus, Simona Corraine Seizure - European Journal of Epilepsy Volume 19, Issue 8, Pages 470-474 (October 2010) DOI: 10.1016/j.seizure.2010.07.001 Copyright © 2010 British Epilepsy Association Terms and Conditions

Fig. 1 (a and b) Plain CT scan performed after the first seizure: hyperdense lesion with marginal hypodensity, mimicking a haemorrhagic infarction in the left temporal lobe. Seizure - European Journal of Epilepsy 2010 19, 470-474DOI: (10.1016/j.seizure.2010.07.001) Copyright © 2010 British Epilepsy Association Terms and Conditions

Fig. 2 (a–c) MRI at clinical onset: FLAIR (a) and PD (b) images indicate a gyral swelling in the left temporal lobe. T2-weighted image (c) shows a signal hyperintensity in the same area. (d) Post-contrast T1-weighted MRI performed 5 months later: necrotic mass with irregular contrast enhancement, consistent with glioblastoma. Seizure - European Journal of Epilepsy 2010 19, 470-474DOI: (10.1016/j.seizure.2010.07.001) Copyright © 2010 British Epilepsy Association Terms and Conditions

Fig. 3 (a–c) MRI at clinical onset: FLAIR (a) and PD (b) images show a tiny area of signal hyperintensity in the right middle temporal gyrus. (c) T1-weighted image: spot of signal hypointensity in the same area. (d) Gadolinium-enhanced MRI after 2 months: necrotic lesion with mural nodule and rim-contrast enhancement, expression of III grade anaplastic oligodendroglioma. Seizure - European Journal of Epilepsy 2010 19, 470-474DOI: (10.1016/j.seizure.2010.07.001) Copyright © 2010 British Epilepsy Association Terms and Conditions

Fig. 4 (a–c) MRI at clinical onset: FLAIR (a) and T2-weighted (b) images indicate hyperintense abnormalities in the left TPO region. (c) Tiny nodular contrast enhancement after gadolinium. (d) Post-contrast T1-weighted MRI after 2 months: evidence of glioblastoma. Seizure - European Journal of Epilepsy 2010 19, 470-474DOI: (10.1016/j.seizure.2010.07.001) Copyright © 2010 British Epilepsy Association Terms and Conditions