Differential expression of select miRNAs was validated in a second cohort of patients. Differential expression of select miRNAs was validated in a second.

Slides:

Advertisements

Similar presentations

a b c Additional File 6 qPCR validation of miRNA expression profiles

Advertisements

a b SUM149PT Motility Invasion C V C V

Among Medicare beneficiaries >65 years old with a index hospitalization at the time of dialysis initiation, use of post-acute SNF care was common. Among.

Patient disposition for the double-blind study period.

Positive interactions between the basic and translational research, clinical research, patient care, and training components of an academic dialysis access.

Pioglitazone treatment prevents TRPC6 overexpression and podocyte injury in the adriamycin (ADRIA)–induced nephropathy rat model for FSGS. ADRIA-induced.

PDE5A is expressed by podocytes.

Inhibition of ILK by QLT-0267 reduces β-catenin accumulation and inhibits Snail1 expression in obstructive nephropathy. Inhibition of ILK by QLT-0267 reduces.

Relationship between urinary TNF-α and RANTES excretion

Podocyte-specific PPAR-γ–deficient mice show increased glomerular TRPC6 expression. Podocyte-specific PPAR-γ–deficient mice show increased glomerular TRPC6.

Absolute and Relative Quantification of Placenta-Specific MicroRNAs in Maternal Circulation with Placental Insufficiency–Related Complications Ilona.

Figure 1. Relationship between (A) total antioxidative activity (TAA) and endothelium-dependent vasodilation (EDV) (r = 0.41, P = 0.016), (B) lag phase.

Patients with SLE have elevated ERV expression.

Characterization of microRNA transcriptome in tumor, adjacent, and normal tissues of lung squamous cell carcinoma Jun Wang, MD, PhD, Zhi Li, MD, PhD,

Studies reporting the incident rate for ischemic steal syndrome per 1000 patient days. Studies reporting the incident rate for ischemic steal syndrome.

Figure 3. Severity of aortic atherosclerosis in apo-E −/− mice with CRF. Aortic plaque area fraction (A), aortic cholesterol content (B), and aortic root.

Pedigrees of the families of patients 1 and 2 show that the clinical phenotype co-segregates with compound heterozygous CLDN10 variants. Pedigrees of the.

Probability of cumulative incidence of ESRD, disease-related death, or death from other cause for the entire cohort. Probability of cumulative incidence.

Schematic representations of DGKE protein and mRNA illustrating the relative positions of all pathogenic mutations reported to date. Schematic representations.

MicroRNA expression in the human blastocyst

Cytokine and chemokine expression of flucloxacillin-specific T cell clones (TCC) of patient P1. Cytokine and chemokine expression of flucloxacillin-specific.

T cell receptor Vβ (TCR-Vβ) expression in a drug-specific T cell line (TCL) and specificity assay of a TCL of patient P1. T cell receptor Vβ (TCR-Vβ) expression.

Studies reporting the incident rate for all types of infections per 1000 patient days. Studies reporting the incident rate for all types of infections.

Several microRNAs are differentially expressed in the glomeruli between different types of kidney disease. Several microRNAs are differentially expressed.

MicroRNAs of rat articular cartilage at different developmental stages identified by Solexa sequencing J. Sun, N. Zhong, Q. Li, Z. Min, W. Zhao, Q. Sun,

INT-767 treatment prevents the increase in renal HIF and Glut1 expression and ER stress in diabetic DBA/2J mice. INT-767 treatment prevents the increase.

Follicular fluid and mural granulosa cells microRNA profiles vary in in vitro fertilization patients depending on their age and oocyte maturation stage

The proportion of DCD donor kidneys discarded was correlated with the proportion of NBD donor kidneys discarded within DSAs (Pearson correlation coefficient.

The incidence of all cause graft failure, and death with a functioning graft was higher in patients who received a DCD donor transplant with total donor.

VEGF signals via a paracrine loop to VEGFR-2 in the glomerulus.

Model of human CLC-Kb transporter topology and positions of amino acid exchanges due to mutations in the CLCNKB gene as identified in Bartter syndrome.

Volume 85, Issue 2, Pages (January 2014)

Mitochondria-associated membranes in proximal tubules after ischemia.

Cocaine exposure downregulates miR-125b expression.

Novel p53 target genes identified by RNA-Seq, pSILAC and ChIP-Seq.

The similar shifts of gut microbiota in IBD across cohorts.

Classification by HtTKV0 and age at HtTKV0 predicts the change in eGFR over time in class 1 patients. Classification by HtTKV0 and age at HtTKV0 predicts.

Patient disposition. Patient disposition. AE, adverse event. *One patient died during the follow-up period. ^Four of the 12 discontinuations of treatment.

(A through C) Mean eGFR during follow-up according to treatment assignment in patients with normoalbuminuria (A), microalbuminuria (B), and macroalbuminuria.

Urine ammonia is highly correlated with plasma K

Toray microarray analysis of the four groups of patients (A) and in patients with calcium score >100 (B). Toray microarray analysis of the four groups.

Synaptopodin expression is also in cells on Bowman’s capsule in juvenile human kidney. Synaptopodin expression is also in cells on Bowman’s capsule in.

UMOD and ACSM2A expressions correlate with renal function.

Vitamin K2 supplementation reduces dp-ucMGP but not dp-cMGP levels in dialysis patients. Vitamin K2 supplementation reduces dp-ucMGP but not dp-cMGP levels.

Box plots showing the relative difference in distribution of mtDNA copy number per cell between patients with ESRD and healthy control subjects frequency.

Fig. 1. Expression of the five miRNAs encoded by two miRNA clusters in mouse sperm and oocytes.(A) qPCR analyses of levels of miR-16 (positive control),

Distribution of podocyte gene mutations in patients with genetic congenital nephrotic syndrome (CNS) and steroid–resistant nephrotic syndrome (SRNS). Distribution.

A glomerulus from a patient who developed nephrotic syndrome while receiving a nonsteroidal anti-inflammatory drug for arthritis. A glomerulus from a patient.

Initial analysis of the transcriptional effects in eight carbon storage mutants (1 to 8; ΔphbA, phbB::ΩSpSm, ΔphbAB, ΔphbC, ΔphaZ, ΔbdhA, acsA2::Tn5, glgA1ΔPstI)

CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional profile. CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional.

MiRNA expression profiling in adipocytes from wild-type (WT) and leptin-deficient ob/ob mice. miRNA expression profiling in adipocytes from wild-type (WT)

Ionized-to-total magnesium (Mg) and calcium (Ca) ratios are lower in patients on hemodialysis than those in patients not on dialysis. Ionized-to-total.

Fig. 1. Expression of the five miRNAs encoded by two miRNA clusters in mouse sperm and oocytes.(A) qPCR analyses of levels of miR-16 (positive control),

Enrichment of miRNAs among DPAR genes and their relative expression under dietary restriction. Enrichment of miRNAs among DPAR genes and their relative.

Ca2+ infusion rates during all three protocol versions.

Expression profiles of 87 miRNAs expressed in SC

Graph showing percentage of total patients with PTD or IGT that would be detected in each category of FBG if an oral glucose tolerance test were performed.

Distribution of vascular access type (2002–2011) among countries with stable or decreasing catheter burden over time. Distribution of vascular access type.

MicroRNA-22-3p is down-regulated in the plasma of Han Chinese patients with premature ovarian failure Yujie Dang, M.D., Ph.D., Shidou Zhao, Ph.D., Yingying.

Kaplan-Meier analysis for the cumulative percentage of patients who remained hospitalized according to presence or absence of ARF with or without other.

We identified 200 Android and 178 iOS apps using 4 search terms and narrowed this to 12 Android apps, 11 iOS apps, and 5 dual-platform apps after applying.

Correlation of miR-21 expression levels with DEGs in 28 bladder cancer cell lines. Correlation of miR-21 expression levels with DEGs in 28 bladder cancer.

Distribution of percent consistent facility aspirin use.

Immunohistochemical and immunogluorescence analysis of renal biopsies showing significant C5b-9, C4d and C3c deposition but almost absent Bb deposition.

Discovered and replicated positive correlation between miR-193b

New dialysis starts in the United States by year in patients with and without diagnosis of diabetes. New dialysis starts in the United States by year in.

Separation in achieved BP levels between the two intervention groups in the SPRINT participants with CKD. The broken line and open circles denote the intensive.

As the patient nears the end of life (dashed arrow), there is an increasing focus on symptom control and patient goals of care and a shift in the approach.

miR-146a is highly expressed selectively on γδ27− T cells.

MiR-1254 and miR-574-5p: Serum-Based microRNA Biomarkers for Early-Stage Non- small Cell Lung Cancer Kristen M. Foss, BS, Chao Sima, PhD, Donatella Ugolini,

Presentation transcript:

Differential expression of select miRNAs was validated in a second cohort of patients. Differential expression of select miRNAs was validated in a second cohort of patients. (A) Abundance of miR-146a-5p and miR-24-3p in glomerular samples from additional patients with DN and FSGS on the basis of qPCR analysis. (B) Log2 fold differences of FSGS/DN from microRNA-sequencing analysis of original samples and qPCR analysis of new validation samples. *P<0.05; P=0.17 for miR-24-3p. Maria Angeles Baker et al. JASN 2017;28:2985-2992 ©2017 by American Society of Nephrology