Methods used in the molecular epidemiology of tuberculosis P. Moström, M. Gordon, C. Sola, M. Ridell, N. Rastogi  Clinical Microbiology and Infection  Volume 8, Issue 11, Pages 694-704 (November 2002) DOI: 10.1046/j.1469-0691.2002.00460.x Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 The binary results of spoligotyping. Spoligotyping has also been used to define subspecies-specific signatures within the various members of the Mycobacterium tuberculosis complex. Some of these specific signatures are illustrated in the figure; e.g., M. bovis shows a characteristic absence of spacers 39 to 43, whereas the recently described M. bovis subsp. caprae shows the absence of spacers 1-16. Clinical Microbiology and Infection 2002 8, 694-704DOI: (10.1046/j.1469-0691.2002.00460.x) Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 A schematic picture of the gene sequences replicated using DRE-PCR. Variability of inter IS6110-PGRS yields different sizes of PCR-products, as illustrated by gel electrophoresis [42]. Clinical Microbiology and Infection 2002 8, 694-704DOI: (10.1046/j.1469-0691.2002.00460.x) Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions