PRIONS.

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Presentation transcript:

PRIONS

What is a Prion? Infectious agent that is composed primarily of protein Polypeptide = amino acid chain = protein Can be one or many polypeptides

What do they do? Cause memory changes Impair brain function Personality changes Decline in intellectual function (dementia) Problems with movement that worsen over time

Prion Diseases Human Prion Diseases Animal Prion Diseases CJD = Creutzfekdt-Jakob Disease vCJD = Variant Creutzfelt-Jakob Disease GSS = Gerstmann-Straussler-Scheinker Syndrome FFI = Fatal Familial Insomnia Kuru = New Guinea Animal Prion Diseases BSE = Bovine Spongiform Encephalopathy = Cow = “Mad Cow” CWD = Chronic Wasting Disease = Elk, Deer, Moose Scrapie = Sheep TME = Transmissible mink encephalopathy Feline spongiform encephalopathy Ungulate spongiform encephalopathy

Who Gets Prion Diseases? 1/per million affected worldwide each year Approximately 300 cases annually in the USA Rarely genetic

Is There a Cure? Currently, there is no cure for any prion disease Prions cannot be destroyed through cooking, heating, radiation, bleach, auto-claving, etc.

http://www. youtube. com/watch http://www.youtube.com/watch?v=ujK7KiLt0s8 (NOVA) 52 mins: Published on Nov 18, 2013 http://www.youtube.com/watch?v=pqhpVpafjmk (Prions: short ~ 1:40) http://www.youtube.com/watch?v=VgB9sg5dy8w MAD COW: USA - Published on Apr 24, 2012

Kuru: https://www.youtube.com/watch?v=vw_tClcS6To (52:10) http://www.cdc.gov/ncidod/teachers_tools/virus_encounters.htm