Important port for SHIP-1 at Dok-3

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Important port for SHIP-1 at Dok-3 by Kerry S. Campbell Blood Volume 110(1):3-4 July 1, 2007 ©2007 by American Society of Hematology

Structural elements and known binding partners of Dok-3. Structural elements and known binding partners of Dok-3. Dok-3 interacts with various signaling proteins via a PTB domain and several C-terminal phosphorylated (p) tyrosine (Y) residues. Known interactions are indicated by double-sided arrows. The pleckstrin homology (PH) domain can interact with phosphatidylinositol 3,4,5-trisphosphate (PIP3) at the plasma membrane. Kerry S. Campbell Blood 2007;110:3-4 ©2007 by American Society of Hematology