Claudia Sommer, MD, Giorgio Cruccu, MD

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Topical Treatment of Peripheral Neuropathic Pain: Applying the Evidence Claudia Sommer, MD, Giorgio Cruccu, MD Journal of Pain and Symptom Management Volume 53, Issue 3, Pages 614-629 (March 2017) DOI: 10.1016/j.jpainsymman.2016.09.015 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 Response rate after treatment with lidocaine 5% medicated plaster or pregabalin in patients with PHN and DPN (PPS).27CI = confidence interval; DPN = painful diabetic polyneuropathy; PHN = post-herpetic neuralgia; PPS = per protocol set. “*” Indicates below the predefined margin for noninferiority of −8 percentage points. Journal of Pain and Symptom Management 2017 53, 614-629DOI: (10.1016/j.jpainsymman.2016.09.015) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Treatment-emergent and drug-related adverse events with lidocaine 5% medicated plaster and pregabalin (SAS).27 AE = adverse event; SAS = safety analysis set. Journal of Pain and Symptom Management 2017 53, 614-629DOI: (10.1016/j.jpainsymman.2016.09.015) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 Achievement of a ≥30% decrease in NPRS score from baseline to Week 8 (FAS) with capsaicin 8% patch vs. pregabalin.15 CI = confidence interval; FAS = full analysis set; NPRS = Numeric Pain Rating Scale. Journal of Pain and Symptom Management 2017 53, 614-629DOI: (10.1016/j.jpainsymman.2016.09.015) Copyright © 2017 The Authors Terms and Conditions

Fig. 4 Treatment satisfaction scores for medication use at Week 8 with capsaicin 8% patch vs. pregabalin.15 CI = confidence interval; LS = least square; TSQM = Treatment Satisfaction Questionnaire for Medication. Journal of Pain and Symptom Management 2017 53, 614-629DOI: (10.1016/j.jpainsymman.2016.09.015) Copyright © 2017 The Authors Terms and Conditions