Cost-utility analysis of rufinamide versus topiramate and lamotrigine for the treatment of children with Lennox–Gastaut Syndrome in the United Kingdom  Lara Verdian, Yunni Yi  Seizure - European Journal of Epilepsy  Volume 19, Issue 1, Pages 1-11 (January 2010) DOI: 10.1016/j.seizure.2009.10.003 Copyright © 2009 British Epilepsy Association Terms and Conditions

Fig. 1 Markov decision analytic model structure. Abbreviations: RUF, rufinamide; TPM, topiramate; LTG, lamotrigine; WC75, drop attacks are really well controlled (≥75% reduction in drop attacks from baseline); WC50, drop attacks are well controlled (≥50% and <75% reduction in drop attacks from baseline); NC, non-responders where drop attacks are not well controlled (<50% reduction in drop attacks from baseline). Seizure - European Journal of Epilepsy 2010 19, 1-11DOI: (10.1016/j.seizure.2009.10.003) Copyright © 2009 British Epilepsy Association Terms and Conditions

Fig. 2 Cost-effectiveness plane comparing RUF with TPM and LTG. Abbreviations: RUF, rufinamide; TPM, topiramate; LTG, lamotrigine; QALYs, quality-adjusted life-years; GBP, Great British Pounds. Seizure - European Journal of Epilepsy 2010 19, 1-11DOI: (10.1016/j.seizure.2009.10.003) Copyright © 2009 British Epilepsy Association Terms and Conditions

Fig. 3 Uncertainty by covariates for RUF versus (A) TPM and (B) LTG in the base case scenario (TTO utilities) Abbreviation: QALYs, quality-adjusted life-years. Seizure - European Journal of Epilepsy 2010 19, 1-11DOI: (10.1016/j.seizure.2009.10.003) Copyright © 2009 British Epilepsy Association Terms and Conditions

Fig. 4 Cost-effectiveness acceptability curves for RUF, TPM and LTG using TTO utilities. Abbreviations: RUF, rufinamide; TPM, topiramate; LTG, lamotrigine; QALYs, quality-adjusted life-years; GBP, Great British Pounds. Seizure - European Journal of Epilepsy 2010 19, 1-11DOI: (10.1016/j.seizure.2009.10.003) Copyright © 2009 British Epilepsy Association Terms and Conditions

Fig. 5 One-way sensitivity analysis of RUF versus TPM. Abbreviations: RUF, rufinamide; TPM, topiramate; WC75, drop attacks are really well controlled (≥75% reduction in drop attacks from baseline); WC50, drop attacks are well controlled (≥50% and <75% reduction in drop attacks from baseline); NC, non-responders where drop attacks are not well controlled (<50% reduction in drop attacks from baseline); Tx, treatment. Seizure - European Journal of Epilepsy 2010 19, 1-11DOI: (10.1016/j.seizure.2009.10.003) Copyright © 2009 British Epilepsy Association Terms and Conditions

Fig. 6 One-way sensitivity analysis of RUF versus LTG. Abbreviations: RUF, rufinamide; LTG, lamotrigine; WC75, drop attacks are really well controlled (≥75% reduction in drop attacks from baseline); WC50, drop attacks are well controlled (≥50% and <75% reduction in drop attacks from baseline); NC, non-responders where drop attacks are not well controlled (<50% reduction in drop attacks from baseline). Seizure - European Journal of Epilepsy 2010 19, 1-11DOI: (10.1016/j.seizure.2009.10.003) Copyright © 2009 British Epilepsy Association Terms and Conditions