MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia by Agostino Tafuri, Chiara.

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Presentation transcript:

MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia by Agostino Tafuri, Chiara Gregorj, Maria T. Petrucci, Maria R. Ricciardi, Marco Mancini, Giuseppe Cimino, Cristina Mecucci, Alessandra Tedeschi, Giuseppe Fioritoni, Felicetto Ferrara, Francesco Di Raimondo, Eugenio Gallo, Vincenzo Liso, Francesco Fabbiano, Nicola Cascavilla, Giovanni Pizzolo, Andrea Camera, Fabrizio Pane, Francesco Lanza, Daniela Cilloni, Luciana Annino, Antonella Vitale, Maria L. Vegna, Marco Vignetti, Robin Foà, and Franco Mandelli Blood Volume 100(3):974-981 August 1, 2002 ©2002 by American Society of Hematology

Flow cytometric detection of MDR1/P-gp expression Flow cytometric detection of MDR1/P-gp expression.Flow cytometric histograms of MDR1 expression in the VBL cell line by single staining with the MRK16 mAb (A), analyzed according to the Kolmogorov-Smirnov test (B). Flow cytometric detection of MDR1/P-gp expression.Flow cytometric histograms of MDR1 expression in the VBL cell line by single staining with the MRK16 mAb (A), analyzed according to the Kolmogorov-Smirnov test (B). Dot plots of a representative ALL sample in which leukemic cells were identified by double staining with IgG2a/CD19 (C) and MRK16/CD19 (D). Histogram (E) made according to the method of Kolmogorov-Smirnov36 to compare fluorescence of the IgG2a isotypic control (black) with the MRK16 (white) mAb. Agostino Tafuri et al. Blood 2002;100:974-981 ©2002 by American Society of Hematology

Flow cytometric detection of MDR1 function by rhodamine-123 efflux Flow cytometric detection of MDR1 function by rhodamine-123 efflux.Flow cytometric dot plots and histograms of MDR1 function in a representative T-ALL sample as measured by the Rhd-123 efflux test without (A, C) and with (B, D) the verapamil MDR modulator. Flow cytometric detection of MDR1 function by rhodamine-123 efflux.Flow cytometric dot plots and histograms of MDR1 function in a representative T-ALL sample as measured by the Rhd-123 efflux test without (A, C) and with (B, D) the verapamil MDR modulator. Agostino Tafuri et al. Blood 2002;100:974-981 ©2002 by American Society of Hematology

Association between MDR1/P-gp expression and CR achievement in B- and T-ALL.CR rates among B-lineage (A) and T-lineage (B) ALL patients with negative (black bar) or positive (white bar) MDR1 expression. Association between MDR1/P-gp expression and CR achievement in B- and T-ALL.CR rates among B-lineage (A) and T-lineage (B) ALL patients with negative (black bar) or positive (white bar) MDR1 expression. Ninety-seven of 126 MDR-negative B-ALL patients achieved CR compared with 19 of 32 MDR-positive patients; 28 of 31 MDR-negative T-ALL patients achieved CR compared with 4 of 11 MDR-positive patients. Agostino Tafuri et al. Blood 2002;100:974-981 ©2002 by American Society of Hematology

OS according to MDR1 expression in ALL OS according to MDR1 expression in ALL.OS duration in MDR1-positive and MDR1-negative patients treated according to the GIMEMA ALL0496 protocol. OS according to MDR1 expression in ALL.OS duration in MDR1-positive and MDR1-negative patients treated according to the GIMEMA ALL0496 protocol. Agostino Tafuri et al. Blood 2002;100:974-981 ©2002 by American Society of Hematology