Left ventricular and aortic dysfunction in cystic fibrosis mice

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Date of download: 9/19/2016 Copyright © The American College of Cardiology. All rights reserved. From: Assessment of aortic regurgitation by transesophageal.

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Presentation transcript:

Left ventricular and aortic dysfunction in cystic fibrosis mice Zachary M. Sellers, Attila Kovacs, Carla J. Weinheimer, Philip M. Best Journal of Cystic Fibrosis Volume 12, Issue 5, Pages 517-524 (September 2013) DOI: 10.1016/j.jcf.2012.11.012 Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 ΔF508 CFTR mice show increased baseline cardiac activity. LV hemodynamic measurements were performed in WT (n=9) and ΔF508 (n=12) mice via catheterization. Each circle represents a single mouse, while the line represents the mean. Journal of Cystic Fibrosis 2013 12, 517-524DOI: (10.1016/j.jcf.2012.11.012) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 CFTR mutation causes increase in the aortic stiffness. In vivo, aortic compliance was measured using echocardiography in WT and ΔF508 mice (n=10). A. Representative images of WT and ΔF508 aortic arches using M-mode images presented with values for mean internal diameters (ID) of aorta (Ao) during diastole (d) and systole (s). B. Distensibility was calculated as the relative change in diameter between systole and diastole. C. Pulse wave velocity-measured aortic stiffness. D. Representative Doppler flow images during 2cycles of systole and diastole through the aortic arches of WT and ΔF508 mice. The straight line represents zero blood velocity with below the line showing velocity of forward flow as blood moves away from probe and above the line showing velocity of retrograde flow as blood moves towards probe. Values for the mean forward and retrograde velocities are presented. All values are presented as means±SEM. *, P<0.05; **, P<0.01; ***, P<0.001 vs. WT by Student's t-test. Journal of Cystic Fibrosis 2013 12, 517-524DOI: (10.1016/j.jcf.2012.11.012) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Decreased cardiac reserve in ΔF508 mice during β-adrenergic stimulation. LV catheterization-measured hemodynamic changes following stimulation with serial concentrations of the β1-adrenergic agonist dobutamine in WT (n=9) and ΔF508 (n=12) mice. Data are shown as percent change from the respective baseline (Fig. 1) for each concentration. Values are expressed as means±SEM. *, P<0.05; **, P<0.01; ***, P<0.001 vs. WT by Student's t-test. Journal of Cystic Fibrosis 2013 12, 517-524DOI: (10.1016/j.jcf.2012.11.012) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions