Molecular pathogenesis of follicular cell derived thyroid cancers

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Molecular pathogenesis of follicular cell derived thyroid cancers Rajeev Parameswaran, Susan Brooks, Gregory Paul Sadler International Journal of Surgery Volume 8, Issue 3, Pages 186-193 (January 2010) DOI: 10.1016/j.ijsu.2010.01.005 Copyright © 2010 Surgical Associates Ltd Terms and Conditions

Fig. 1 International Journal of Surgery 2010 8, 186-193DOI: (10.1016/j.ijsu.2010.01.005) Copyright © 2010 Surgical Associates Ltd Terms and Conditions

Fig. 2 Multistep carcinogenesis model of thyroid cancer formation. Formation of benign thyroid tumours occurs as a result of alteration of various growth factors. The follicular neoplasms are formed from thyrocytes by mutations of ras and other factors as shown in the figure. Papillary cancers are formed by alterations in RET/PTC and other oncogenes. The undifferentiated tumours are formed from the differentiated tumours by mutations of tumour suppressor genes. International Journal of Surgery 2010 8, 186-193DOI: (10.1016/j.ijsu.2010.01.005) Copyright © 2010 Surgical Associates Ltd Terms and Conditions