Mutagenic potential of temozolomide in bone marrow cells in vivo

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Mutagenic potential of temozolomide in bone marrow cells in vivo by Hartmut Geiger, David Schleimer, Kalpana J. Nattamai, Stefanie R. Dannenmann, Stella M. Davies, and Brian D. Weiss Blood Volume 107(7):3010-3011 April 1, 2006 ©2006 by American Society of Hematology

Strong mutagenic potential of TMZ in vivo. Strong mutagenic potential of TMZ in vivo. (A) Mutation frequency of BM cells derived from animals treated with either CP or TMZ in vivo, measured with the small blue mouse mutation indicator strain. (B) Frequency of point mutations (PM) in BM cells derived from animals treated with either CP or TMZ in vivo. Values shown are mean ± 1 SEM; n = 18 for untreated/vehicle, n = 4 for CP, and n = 4 for CP. *P < .05. Hartmut Geiger et al. Blood 2006;107:3010-3011 ©2006 by American Society of Hematology