Penetrance of Hemochromatosis in HFE Genotypes Resulting in p

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Penetrance of Hemochromatosis in HFE Genotypes Resulting in p Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network Carlos J. Gallego, Amber Burt, Agnes S. Sundaresan, Zi Ye, Christopher Shaw, David R. Crosslin, Paul K. Crane, S. Malia Fullerton, Kris Hansen, David Carrell, Helena Kuivaniemi, Kimberly Derr, Mariza de Andrade, Catherine A. McCarty, Terrie E. Kitchner, Brittany K. Ragon, Sarah C. Stallings, Gabriella Papa, Joseph Bochenek, Maureen E. Smith, Sharon A. Aufox, Jennifer A. Pacheco, Vaibhav Patel, Elisha M. Friesema, Angelika Ludtke Erwin, Omri Gottesman, Glenn S. Gerhard, Marylyn Ritchie, Arno G. Motulsky, Iftikhar J. Kullo, Eric B. Larson, Gerard Tromp, Murray H. Brilliant, Erwin Bottinger, Joshua C. Denny, Dan M. Roden, Marc S. Williams, Gail P. Jarvik The American Journal of Human Genetics Volume 97, Issue 4, Pages 512-520 (October 2015) DOI: 10.1016/j.ajhg.2015.08.008 Copyright © 2015 The Authors Terms and Conditions

Figure 1 Kaplan-Meier Curves of HH Diagnosis Frequency of HH diagnosis by age and sex separately for HFE p.Cys282Tyr homozygotes and p.[Cys282Tyr];[His63Asp] compound heterozygotes. Each crosshair represents a new HH diagnosis. The American Journal of Human Genetics 2015 97, 512-520DOI: (10.1016/j.ajhg.2015.08.008) Copyright © 2015 The Authors Terms and Conditions