Oral Sildenafil Reduces Pulmonary Hypertension After Cardiac Surgery

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Presentation transcript:

Oral Sildenafil Reduces Pulmonary Hypertension After Cardiac Surgery Aaron L. Trachte, MD, Emilio B. Lobato, MD, Felipe Urdaneta, MD, Phillip J. Hess, MD, Charles T. Klodell, MD, Tomas D. Martin, MD, Edward D. Staples, MD, Thomas M. Beaver, MD The Annals of Thoracic Surgery Volume 79, Issue 1, Pages 194-197 (January 2005) DOI: 10.1016/j.athoracsur.2004.06.086 Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Values of mean arterial pressure (MAP; ♦) and mean pulmonary arterial pressure (MPAP; ■) before and after the administration of a single dose of oral sildenafil. There was a reduction in MPAP without a clinically significant change in MAP. The Annals of Thoracic Surgery 2005 79, 194-197DOI: (10.1016/j.athoracsur.2004.06.086) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Changes in systemic vascular resistance index (♦) and pulmonary vascular resistance index (PVRI; ■) following the administration of sildenafil. The effect on PVRI is more pronounced, denoting relative pulmonary selectivity. The Annals of Thoracic Surgery 2005 79, 194-197DOI: (10.1016/j.athoracsur.2004.06.086) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions