Life without Centrioles: Cilia in the Spotlight

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Life without Centrioles: Cilia in the Spotlight Jose L. Badano, Nicholas Katsanis  Cell  Volume 125, Issue 7, Pages 1228-1230 (June 2006) DOI: 10.1016/j.cell.2006.06.013 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Centrioles in Cell Division and Ciliogenesis (Upper panel) During the cell cycle, centrioles replicate and migrate to form the poles of the mitotic spindle, which are necessary for the segregation of chromosomes. However, centriolar dysfunction affects cell division differently in Drosophila and mammals. (Lower panel) Centrioles play a critical role in the formation of the basal body and the cilium. Consequently, centriolar loss might result in different phenotypic outcomes dictated by each species' dependency on ciliary function. Cell 2006 125, 1228-1230DOI: (10.1016/j.cell.2006.06.013) Copyright © 2006 Elsevier Inc. Terms and Conditions