Christopher K. Zarins, MD, Chengpei Xu, MD, Seymour Glagov, MD

Slides:

Advertisements

Similar presentations

The effect of inguinal lymphatic manipulation on regional lymph flow patterns Jeffrey R. Rubin, MD, Lisa B. Eberlin, MD Journal of Vascular Surgery Volume.

Advertisements

Development and regression of intimal thickening of arterially transplanted autologous vein grafts in dogs Kazumasa Morinaga, M.D., Hiroshi Eguchi, M.D.,

Large renal artery aneurysm in Takayasu arteritis

Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model Colleen M. Brophy, MD, Joan E.

Frank W. Sellke, M. D. , Gary B. Williams, M. D. , Duane L. Donovan, M

Richard T. Purdy, M. D. , Frederick C. Beyer, M. D. , William D

Atherosclerotic aneurysm formation in an in situ saphenous vein graft

Mycotic axillary artery aneurysm

Mark Wengrovitz, MD. , Lulseged G. Selassie, MD. , Robert R. M

PC222. Loss of Normal Fiber Orientation in Human Abdominal Aortic Aneurysmal Tissue and Increased Energy Loss Sandra Toth, BS, Doran Mix, MD, BS, Ibrahima.

Abdominal Aorta Aneurysms in Children: Single-Center Experience of Six Patients Caisheng Ye, MD, PhD, Henghui Yin, MD, PhD, Ying Lin, MD, PhD, Li Zhou,

Aneurysm formation in experimental atherosclerosis: Relationship to plaque evolution Christopher K. Zarins, MD, Seymour Glagov, MD, Dragoslava Vesselinovitch,

Dennis R. Holmes, MD, William Wester, BA, Robert W

Suzanne Menashi, Ph. D. , Juan S. Campa, B. Sc. , Roger M

Jing Wen, MD, Peiyi Wang, MS, Sumona V. Smith, MD, Carolyn A

Malcolm O. Perry, MD, Richard Kempczinski, MD

Adventitial elastolysis is a primary event in aneurysm formation

Conformational stress and anastomotic hyperplasia

Paul H. Schoof, MDa, Adriana C

Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease Jonathan R. Boyle, FRCS, Edward McDermott,

Thomas Reifsnyder, MD, Jonathan B. Towne, MD, Gary R

Adventitial cystic disease of the popliteal artery: Failure of percutaneous transluminal angioplasty as a therapeutic modality Robert L. Fox, M.D., Mark.

Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model Colleen M. Brophy, MD, Joan E.

William W. Lin, BA, Gregory S. McGee, MD, Bruce K

Hisham S. Bassiouny, MD, Yashuhiro Sakaguchi, MD, Susanne A

Abdominal aortic aneurysm: A general defect in the vasculature with focal manifestations in the abdominal aorta? Björn Sonesson, MD, PhD, Flemming Hansen,

Bacterial resistance of refrigerated and cryopreserved aortic allografts in an experimental virulent infection model Pierre-Yves Litzler, MD, Pascale.

Hemodynamic stress and experimental aortoiliac atherosclerosis

Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors Shixiong Liao, MSa, Manuel.

Multiple idiopathic arterial aneurysms in children: A case report and review of the literature Vivienne Halpern, MD, James O'Connor, MD, Marianne Murello,

Jennifer Engle, MD, Hazim J. Safi, MD, Omid Abbassi, MD, Dimitrios C

Objective tinnitus resulting from internal carotid artery stenosis

Robert A. McCready, M. D. , Margaret A. Price, B. S. , Richard J

Changes in arterial wall compliance after endovascular stenting

S.Amjad Hussain, MD, FRCSC, Ahmet Bayar, MD

The occluded renal artery: Durability of revascularization

Boulos Toursarkissian, MD, David Schwartz, MD, PhD, Paul R

Immunosuppressive treatment of aortic allografts

Vein interposition cuffs decrease the intimal hyperplastic response of polytetrafluoroethylene bypass grafts Mark Kissin, MD, Nikhil Kansal, MD, Peter.

Polyurethane vascular prostheses decreases neointimal formation compared with expanded polytetrafluoroethylene Marc G. Jeschke, MD, Valentin Hermanutz,

The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms David A. Bigatel, MD, James R. Elmore, MD, David.

Calvin B. Ernst, MD Journal of Vascular Surgery

Gideon P. Naude, MBChB, FRCS(Edin), Martin Back, MD, Malcolm O

Ruptured abdominal aortic aneurysm: A population-based study

Ramesh Lokanathan, MD, FRCS(C), David C. Taylor, MD, FRCS(C)

J. Sheppard Mondy, MD, J. Koudy Williams, DVM, Michael R

Thoracoabdominal aortic aneurysm in Cogan’s syndrome

Cardiovascular surgery—The rocket and its stars: Presidential address

Aneurysmal and occlusive atherosclerosis of the human abdominal aorta

Phillip J. Cozzi, B. S. , Ross T. Lyon, M. D. , Harry R. Davis, Ph. D

An experimental study of a new sutureless intraluminal graft with an elastic ring that can attach itself to the vessel wall Masaru Matsumae, MD, Hatsuzo.

Seizures following subclavian-carotid bypass

Critical carotid stenoses: Morphologic and chemical similarity between symptomatic and asymptomatic plaques Hisham S. Bassiouny, MD, Harry Davis, PhD,

Richard J. Sanders, MD 1, William H. Pearce, MD 2

Critical hand ischemia caused by forearm fibromuscular dysplasia

Kim J. Hodgson, M.D., David S. Sumner, M.D.

Malignant fibrous histiocytoma of the aorta

Michael A. Zatina, M. D. , Christopher K. Zarins, M. D. , Bruce L

D. Emerick Szilagyi, MD—An appreciation

Christopher K. Zarins, M. D. , Elliot Weisenberg, M. S

Ross T. Lyon, M. D. , Arthur Runyon-Hass, Ph. D. , Harry R. Davis, Ph

George D. Lilly 1906–1988 Journal of Vascular Surgery

James A. DeWeese, MD Journal of Vascular Surgery

Christopher K. Zarins, M. D. , Michael A. Zatina, M. D. , Don P

Innominate artery trauma: A thirty-year experience

Supraclavicular reoperation for neurogenic thoracic outlet syndrome

Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia—A review Alexander W. Clowes, MD, Michael A. Reidy,

Arterial fibrodysplasia: Rapid progression complicated by rupture of a visceral aneurysm into the gastrointestinal tract G. den Butter, M.D., J.H. van.

Endovascular repair of two abdominal aortic aneurysms

Cornelius A. Sullivan, MD, Michael J. Rohrer, MD, Bruce S. Cutler, MD

Presentation transcript:

Aneurysmal enlargement of the aorta during regression of experimental atherosclerosis Christopher K. Zarins, MD, Chengpei Xu, MD, Seymour Glagov, MD Journal of Vascular Surgery Volume 15, Issue 1, Pages 90-101 (January 1992) DOI: 10.1016/0741-5214(92)70017-F Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Cholesterol levels for the three groups. There is a marked reduction for group III regression animals at 12 months, but not to the baseline level. Journal of Vascular Surgery 1992 15, 90-101DOI: (10.1016/0741-5214(92)70017-F) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Abdominal aortic dimensions for each animal. In group III four of the six animals had larger lumen areas and IEL areas than any of the animals in groups I or II. One animal in group III had a threefold increase in lumen and IEL area compared with group I and II animals and an abdominal aorta 1.2 times larger than the thoracic aorta and was considered to have a manifest aneurysm. Journal of Vascular Surgery 1992 15, 90-101DOI: (10.1016/0741-5214(92)70017-F) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Sections of abdominal aortas of group I (a), group II (b) and group III (c). There was moderate plaque formation after the 6-month induction diet (a). Plaques were much larger and the media was slightly thinner after 12 months on the induction diet, but the artery size (IEL area) did not change significantly (b). After 6 months of the regression diet (c) plaques were significantly smaller and absent in some regions. The media was thin and artery size (IEL area) was significantly increased. (Weigert van Gieson stain; original magnification × 10.) Journal of Vascular Surgery 1992 15, 90-101DOI: (10.1016/0741-5214(92)70017-F) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 4 Sections of thoracic aortas of group I (a), II (b) and III (c). There were no significant differences in artery size or media thickness among the groups. (Weigert van Gieson stain; original magnification × 10.) Journal of Vascular Surgery 1992 15, 90-101DOI: (10.1016/0741-5214(92)70017-F) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 5 Histologic changes in abdominal aorta of each group. After 6 months of the induction diet, group I (a), moderate plaque formed with characteristic foamy cell prevalence and little change in the media. In group II (b), after the 12-month induction diet, plaques were complex with formation of fibrous caps and evidence of necrosis and cholesterol accumulation. Media appeared normal with clearly stained elastic lamellae and smooth muscle cells. After 6-month regression diet, group III (c), plaques were much smaller and largely fibrotic. Media was thinned and elastic lamellae were largely inapparent. (Weigert van Gieson stain; original magnification × 75.) Journal of Vascular Surgery 1992 15, 90-101DOI: (10.1016/0741-5214(92)70017-F) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 6 Thoracic aortas show no significant differences among the groups: group I (a), II (b), and III (c). (Weigert van Gieson stain; original magnification × 75.) Journal of Vascular Surgery 1992 15, 90-101DOI: (10.1016/0741-5214(92)70017-F) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions