Dynamics cross-correlation map for the Cα atom pairs within monomers of TK WT and stable variants. Dynamics cross-correlation map for the Cα atom pairs within monomers of TK WT and stable variants. Correlation coefficient (Cij) was shown as different colors. Cij with values from 0 to 1 represents positive correlations, whereas Cij with values from −1 to 0 represents negative correlations. Mutated sites are marked for WT with horizontal and vertical lines. Haoran Yu, and Paul A. Dalby PNAS 2018;115:47:E11043-E11052 ©2018 by National Academy of Sciences