“Proliferative disorders”

“Proliferative disorders” Proliferation of a clone of cells Lymphoid Myeloid

lymphoproliferative disorders A clone of malignant lymphocytes fills the bone marrow The lymphoid leukaemias are discussed in other presentations

lymphoproliferative disorders The lymphomas Hodgkins’s Lymphoma Non - Hodgkins’ Lymphoma The rare ones: Burkitt’s Lymphoma Mycosis Fungoides Sezary’s Symdrome Conditions can be staged Range of severity of disease

lymphoproliferative disorders Myeloma / Waldenstrom’s Macroglobulinaemia Proliferation of plasma cells All producing one antibody

myeloproliferative disorders A clone of malignant myeloid cells fills the bone marrow The myeloid leukaemias are discussed in other presentations

myeloproliferative disorders Polycythaemia Rubra Vera As opposed to secondary polycythaemias Proliferation of red cell production Often other cell lines proliferate too

myeloproliferative disorders Essential thrombocythaemia Grossly excessive platelet production - >400 x109cells/l

myeloproliferative disorders Myelofibrosis Bone marrow fills with fibrous tissue

myeloproliferative disorders Raised cell counts cause problems: Red cells - circulatory overload Platelets - thrombotic risk

myeloproliferative disorders MPDs are all “preleukemic” and are predisposed to clonal evolution and disease transformation to AML. The propensity to transform into AML differs among the subgroups, being highest for CML (>90%) and least for ET (<5%). Patients with PV have a 10 and 25% chance of transforming into a myelofibrotic stage at 10 and 25 years of follow-up, respectively.