Volume 61, Issue 2, Pages 378-384 (February 2012) A New and Highly Prognostic System to Discern T1 Bladder Cancer Substage  Bas W.G. van Rhijn, Theo H. van der Kwast, Sultan S. Alkhateeb, Neil E. Fleshner, Geert J.L.H. van Leenders, Peter J. Bostrom, Madelon N.M. van der Aa, David M. Kakiashvili, Chris H. Bangma, Michael A.S. Jewett, Alexandre R. Zlotta  European Urology  Volume 61, Issue 2, Pages 378-384 (February 2012) DOI: 10.1016/j.eururo.2011.10.026 Copyright © 2011 European Association of Urology Terms and Conditions

Fig. 1 Examples of T1m and T1e substaging. (a) T1m: a single focus of lamina propria invasion ≤0.5mm (within one high-power field, objective ×40); (b) T1e: specimens showing a >0.5-mm lamina propria invasion or multiple microinvasive areas. In this example, the lamina propria invasion is >0.5mm. European Urology 2012 61, 378-384DOI: (10.1016/j.eururo.2011.10.026) Copyright © 2011 European Association of Urology Terms and Conditions

Fig. 2 Kaplan-Meier analyses for progression of the two substaging systems used in the present series. (a) The Kaplan-Meier analysis for the new system that discerns T1-microinvasive (T1m) and T1-extensive-invasive (T1e) tumors (see Table 2 for further explanation). Five- and 10-yr progression-free intervals were 83% and 57%, respectively, for T1m. Five- and 10-yr progression-free intervals were 55% and 27%, respectively, for T1e. p=0.002 (log-rank test). (b) The Kaplan-Meier analysis for substaging of T1 BCa according to invasion above the muscularis mucosae–vascular plexus (MM-VP) (T1a), in the MM-VP (T1b), or beyond the MM-VP (T1c). Please note that T1b and T1c were grouped in one category, as their outcome was similar. Five- and 10-yr progression-free intervals were 76% and 44%, respectively, for T1a. Five- and 10-yr progression-free intervals were 48% and 26%, respectively, for T1b/T1c. p=0.002 (log-rank test). European Urology 2012 61, 378-384DOI: (10.1016/j.eururo.2011.10.026) Copyright © 2011 European Association of Urology Terms and Conditions

Fig. 3 Kaplan-Meier analyses for disease-specific survival (DSS) of the two substaging systems used in the present series. (a) The Kaplan-Meier analysis for the T1m/T1e substaging system. Five- and 10-yr DSSs were 96% and 75%, respectively, for T1m. Five- and 10-yr DSSs were 81% and 46%, respectively, for T1e. p=0.038 (log-rank test). (b) The Kaplan-Meier analysis for the T1a/T1b/T1c substaging system. Five- and 10-yr DSSs were 89% and 64%, respectively, for T1a. Five- and 10-yr DSSs were 83% and 42%, respectively, for T1b/T1c. p=0.138 (log-rank test). For further explanation, see Figure 1 and 2 and Table 2. European Urology 2012 61, 378-384DOI: (10.1016/j.eururo.2011.10.026) Copyright © 2011 European Association of Urology Terms and Conditions