“Sweet Talk”: Closing in on C Type Lectin Signaling

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“Sweet Talk”: Closing in on C Type Lectin Signaling Friederike Meyer-Wentrup, Alessandra Cambi, Gosse J. Adema, Carl G. Figdor Immunity Volume 22, Issue 4, Pages 399-400 (April 2005) DOI: 10.1016/j.immuni.2005.04.001 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 The Yeast Cell Wall (Zymosan) Can Interact with the PRRs Dectin-1 and TLR2 Receptor triggering has diverse effects, ranging from IL-2 and IL-10 production in the case of Dectin-1 triggering alone to IL-12 and TNF-α production in the case of TLR2 activation. The latter is augmented by cooperative signaling of Dectin-1 with TLR2. One of the future challenges is to determine the mechanisms regulating the interplay between different receptors after pathogen binding. Immunity 2005 22, 399-400DOI: (10.1016/j.immuni.2005.04.001) Copyright © 2005 Elsevier Inc. Terms and Conditions