CMV: when bad viruses turn good

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CMV: when bad viruses turn good by A. John Barrett Blood Volume 118(5):1193-1194 August 4, 2011 ©2011 by American Society of Hematology

Hypothetical mechanisms of a virus-versus-leukemia effect. Hypothetical mechanisms of a virus-versus-leukemia effect. The myeloid reservoir of latent CMV virus includes AML blasts that reactivate after SCT. (1) CMV-specific CTLs kill CMV antigen presented by leukemia; (2) CMV up-regulates LFA-1 in leukemia, increasing susceptibility to NK killing; (3) direct cytotoxic effect of CMV on AML cells. A. John Barrett Blood 2011;118:1193-1194 ©2011 by American Society of Hematology

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