Where does a Staphylococcus aureus vaccine stand?

Slides:

Advertisements

Similar presentations

Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages

Advertisements

Vaccines for the elderly

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

R. Cavallo Clinical Microbiology and Infection

Gram-positive infections: lessons learnt and novel solutions

Analysis of superantigenic toxin Vβ T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shock T. Ferry, D. Thomas,

New epidemiology of Staphylococcus aureus infection in Asia

Immunosuppressive monoclonal antibodies: current and next generation

Comparative genomics and DNA array-based genotyping of pandemic Staphylococcus aureus strains encoding Panton-Valentine leukocidin S. Monecke, B. Berger-Bächi,

G. Cornaglia, A. Lönnroth, M. Struelens

Gut bacterial microbiota and obesity

Incidence and outcome of Staphylococcus aureus endocarditis—a 10-year single-centre northern European experience H. Asgeirsson, A. Thalme, M. Kristjansson,

Molecular characterization of methicillin-resistant Staphylococcus aureus isolated over a 2-year period in a Qatari hospital from multinational patients

Varicella vaccination: a laboured take-off

S. Wagenpfeil, A. Neiss, K. Banz, P. Wutzler

Nosocomial infection caused by class 1 integron-carrying Staphylococcus aureus in a hospital in South China Z. Xu, L. Shi, C. Zhang, L. Zhang, X. Li,

The efficacy and safety of daptomycin: first in a new class of antibiotics for Gram- positive bacteria M.J. Rybak Clinical Microbiology and Infection

Migrant health—a cause for concern?

Clinical characteristics of Haemophilus influenzae meningitis in Denmark in the post- vaccination era T.I. Pedersen, M. Howitz, C. Østergaard Clinical.

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

J.-P. Van geertruyden Clinical Microbiology and Infection

N. Messad, L. Landraud, B. Canivet, G. Lina, J. -L. Richard, A

Analysis of superantigenic toxin Vβ T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shock T. Ferry, D. Thomas,

Link between intracellular pathogens and cardiovascular diseases

Louis Pasteur, from crystals of life to vaccination

How to evaluate and predict the ecologic impact of antibiotics: the pharmaceutical industry view from research and development R. Bax Clinical Microbiology.

Effect of vitamin D3 supplementation on Staphylococcus aureus nasal carriage: a randomized, double-blind, placebo-controlled trial in healthy adults

Use of surveillance cultures and enteral vancomycin to control methicillin-resistant Staphylococcus aureus in a paediatric intensive care unit K. Thorburn,

Surveillance of Legionnaires’ disease in Austria

Nosocomial infection caused by class 1 integron-carrying Staphylococcus aureus in a hospital in South China Z. Xu, L. Shi, C. Zhang, L. Zhang, X. Li,

Vector control: a cornerstone in the malaria elimination campaign

Pharmacodynamics of doxycycline

Immunotherapy of aspergillosis

Tumoral presence of human cytomegalovirus is associated with shorter disease-free survival in elderly patients with colorectal cancer and higher levels.

Rapid detection, differentiation and typing of methicillin-resistant Staphylococcus aureus harbouring either mecA or the new mecA homologue mecALGA251

Emergence and control of an outbreak of infections due to Panton-Valentine leukocidin positive, ST22 methicillin-resistant Staphylococcus aureus in a.

Training for the infectious diseases speciality in Norway

Why is mucormycosis more difficult to cure than more common mycoses?

Low prevalence of methicillin-resistant Staphylococcus aureus with reduced susceptibility to glycopeptides in Belgian hospitals C. Nonhoff, O. Denis,

R. Karakus, K. Caglar, C. Aybay Clinical Microbiology and Infection

Hepatitis C virus and interferon type III (interferon-λ3/interleukin-28B and interferon-λ4): genetic basis of susceptibility to infection and response.

Bacterial resistance—the clinical challenge

Comparative genomics and DNA array-based genotyping of pandemic Staphylococcus aureus strains encoding Panton-Valentine leukocidin S. Monecke, B. Berger-Bächi,

Metagenomics and probiotics

M. Aires-de-Sousa Clinical Microbiology and Infection

Volume 95, Issue 3, Pages (March 2019)

A case of pleurisy associated with antibodies to Rickettsia conorii

Antibacterial drug discovery in the 21st century

Abstracts cont. Clinical Microbiology and Infection

Pandemic lineages of extraintestinal pathogenic Escherichia coli

P.M. Hawkey Clinical Microbiology and Infection

Vaccines for the elderly

Sequential time to positivity of blood cultures can be a predictor of prognosis of patients with persistent Staphylococcus aureus bacteraemia M.-S. Hsu,

G.M. Rossolini, E. Mantengoli Clinical Microbiology and Infection

Statin use and clinical outcomes among pneumonia patients

Clinical Microbiology and Infection

Rise and subsequent decline of community-associated methicillin resistant Staphylococcus aureus ST30-IVc in Copenhagen, Denmark through an effective search.

K. Kaier, N.T. Mutters, U. Frank Clinical Microbiology and Infection

Panton–Valentine leukocidin-encoding bacteriophage and gene sequence variation in community-associated methicillin-resistant Staphylococcus aureus J.A.

The atypical pneumonias: clinical diagnosis and importance

Serum antibodies against Panton–Valentine leukocidin in a normal population and during Staphylococcus aureus infection M. Croze, O. Dauwalder, O. Dumitrescu,

Modelling during an emergency: the 2009 H1N1 influenza pandemic

A. Manzur, F. Gudiol Clinical Microbiology and Infection

B.A. Cunha Clinical Microbiology and Infection

J.L. Balcázar Clinical Microbiology and Infection

G.C. Schito Clinical Microbiology and Infection

Impact of antibiotic restrictions: the patient's perspective

Comparative study of pediculicidal effect of medical plants

CMI readers' survey Clinical Microbiology and Infection

The future of diagnostic bacteriology

Presentation transcript:

Where does a Staphylococcus aureus vaccine stand? V.G. Fowler, R.A. Proctor Clinical Microbiology and Infection Volume 20, Pages 66-75 (May 2014) DOI: 10.1111/1469-0691.12570 Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1. Abbreviations MΦ, macrophage; PSM, phenol-soluble modulins; IL, interleukin; TGF-β, transforming growth factor-β; Th17, T helper type 17 cells; mAb, monoclonal antibody; V710, IsdB antigen used in Merck Vaccine trial; C', complement; SAE, Staphylococcus aureus enterotoxin E; RORγ(, retinoid-related orphan receptor γ; STAT3, signal transducer and activator of transcription 3; Hla, α-toxin; TSST-1, toxic shock syndrome toxin -1; Luk, leucocidin; PVL, Panton-Valentine leucocidin (two component toxin made up of LukS-PV and LukF-PV); IFN-γ, interferon-γ. Clinical Microbiology and Infection 2014 20, 66-75DOI: (10.1111/1469-0691.12570) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions