Fig. 1. Generation of ERY974. Generation of ERY974. (A) Schematic illustration of ERY974 structure and the introduced mutations. The two Fab arms share.

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Fig. 1. Generation of ERY974. Generation of ERY974. (A) Schematic illustration of ERY974 structure and the introduced mutations. The two Fab arms share a common light chain, depicted in green, with a variable domain. (B) Flow cytometry results showing specific binding of ERY974 to GPC3 and CD3E in SK-HEP-1 (a parental human liver/ascites adenocarcinoma cell line), SK-HEP-1/hGPC3, (SK-HEP-1 cells that overexpress human GPC3), BAF3 (a parental mouse pro–B cell line), and BAF3/CD3ε (BAF3 cells that overexpress human CD3E). The blue lines indicate staining with a control IgG4 antibody, and the red lines indicate staining with ERY974. FITC, fluorescein isothiocyanate. Takahiro Ishiguro et al., Sci Transl Med 2017;9:eaal4291 Published by AAAS