Volume 119, Issue 6, Pages (December 2000)

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Volume 119, Issue 6, Pages 1483-1490 (December 2000) Linkage heterogeneity for the IBD1 locus in Crohn's disease pedigrees by disease onset and severity Steven R. Brant, *, Carolien I.M. Panhuysen, ‡, Joan E. Bailey–Wilson, §, Patrick M. Rohal, *, Sinda Lee, ∥, Jasdeep Mann, *, Geoffrey Ravenhill, *, Barbara S. Kirschner, ∥, Stephen B. Hanauer, ∥, Judy H. Cho, ∥, Theodore M. Bayless, * Gastroenterology Volume 119, Issue 6, Pages 1483-1490 (December 2000) DOI: 10.1053/gast.2000.20245 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Mean fNPL scores at marker D16S769 are greater for CD pedigrees stratified by age and greater disease severity than stratified by age alone. Bottom part shows the cumulative number of CD pedigrees with at least one relative diagnosed at or below a given age (x-axis, “Age at Diagnosis”) independent of disease severity (□), or with at least one relative diagnosed at or below a given age and with the requirement of relatively more severe CD in that relative (■). Top part shows corresponding mean fNPL scores. For methodology, see Materials and Methods. Gastroenterology 2000 119, 1483-1490DOI: (10.1053/gast.2000.20245) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 Chromosome 16 two-point NPL analysis in 3 sets of CD families. Markers are listed in their map order on chromosome 16 beginning with the most p-telomeric. The IBD1 candidate region extends from markers D16S403 to D16S3396. IBD1 linkage evidence is greatest for group 1 (severe, early-onset) pedigrees (■), intermediate for all CD pedigrees (●), and minimal for group 2 (no severe, early-onset CD) pedigrees (□). Gastroenterology 2000 119, 1483-1490DOI: (10.1053/gast.2000.20245) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 Chromosome 16 multipoint NPL analysis in 3 sets of CD families. Map distances were taken from the Weber screening set 8.0 markers. The IBD1 candidate region extends from 33 to 50 cM on this map. IBD1 linkage evidence is maximal for group 1 (severe, early-onset) pedigrees (dashed line), intermediate for all CD pedigrees (thick line), and absent for group 2 (no severe, early-onset CD) pedigrees (thin line). Gastroenterology 2000 119, 1483-1490DOI: (10.1053/gast.2000.20245) Copyright © 2000 American Gastroenterological Association Terms and Conditions