Dennis D. Taub, PhD, William B

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Presentation transcript:

Immunity from Smallpox Vaccine Persists for Decades: A Longitudinal Study Dennis D. Taub, PhD, William B. Ershler, MD, Mark Janowski, MD, Andrew Artz, MD, Michael L. Key, Julie McKelvey, Denis Muller, MS, Bernard Moss, MD, PhD, Luigi Ferrucci, MD, PhD, Patricia L. Duffey, Dan L. Longo, MD The American Journal of Medicine Volume 121, Issue 12, Pages 1058-1064 (December 2008) DOI: 10.1016/j.amjmed.2008.08.019 Copyright © 2008 Terms and Conditions

Figure 1 Antivaccinia IgG titers in participants vaccinated one or more times over an 88-year period. (A) Effect of time on vaccinia-specific IgG antibody responses for each group of singly or multiply vaccinated individuals using the banked serum of Baltimore Longitudinal Study of Aging subjects. Serum banked over a 45-year time period on 209 Baltimore Longitudinal Study of Aging study participants was examined using a vaccinia-specific IgG ELISA to determine the antibody titers in subjects vaccinated one or more times over individual follow-up times between 13 and 88 years. Several time points were examined to assess how titers actually changed over time. All serum assay results are represented by individual dots. The lines indicate the repeated measures linear-effects model projection by number of vaccines. The bar (± SEM) at time zero represents the mean titer of the 29 non-vaccinated subjects. (B) Vaccinia-specific IgG titers were compared with the total number of vaccinations received. Serum samples obtained from unvaccinated volunteers (n=29) demonstrated titers <1:4 (Ln 1.39). Bars show the average±SE of antibody production by each group. Bars with different superscripts (a, b, c, d) are significantly different from each other; P <.05. The American Journal of Medicine 2008 121, 1058-1064DOI: (10.1016/j.amjmed.2008.08.019) Copyright © 2008 Terms and Conditions

Figure 2 Neutralizing antivaccinia titers in participants vaccinated one or more times over an 88-year period. (A) Effect of time on neutralizing antivaccinia titers for each group of singly or multiply vaccinated individuals using the banked serum of Baltimore Longitudinal Study of Aging subjects. Serum banked over a 45-year time period on Baltimore Longitudinal Study of Aging study participants was examined using a vaccinia-specific neutralization assay to determine the antibody titers in subjects vaccinated one or more times between over individual follow-up times between 13 and 88 years. For the majority of participants, several time points were examined to assess how titers may actually change over time. All serum assay results are represented by individual dots. The lines indicate the repeated measures linear-effects model projection by number of vaccines. The bar (± SEM) at time zero represents the mean titer of the 29 non-vaccinated subjects. (B) Neutralizing antivaccinia titers were compared with the total number of vaccinations received. The serum samples obtained from unvaccinated volunteers (n=29) demonstrated titers <1:16 (Ln 2.77), with the majority of samples reproducibly measuring below 1:8 (Ln 2.08). Bars show the average±SE of antibody production by each group. Bars with different superscripts (a, b) are significantly different; P <.05. The American Journal of Medicine 2008 121, 1058-1064DOI: (10.1016/j.amjmed.2008.08.019) Copyright © 2008 Terms and Conditions

Figure 3 Comparison of the natural log of vaccinia-specific IgG and neutralization titers among participants with single vaccination, multiple vaccinations, and previous smallpox diagnosis. Bars show the average±SE of antibody production by each group. Vaccinia-specific IgG (A) and neutralization (B) titers in participants with previous smallpox diagnosis were not significantly different from titers in participants with single or multiple vaccinations. However, similar to Figure 1, the vaccinia-specific IgG responses (A) were significantly (P >.05) different between singly versus multiply vaccinated Baltimore Longitudinal Study of Aging subjects. The American Journal of Medicine 2008 121, 1058-1064DOI: (10.1016/j.amjmed.2008.08.019) Copyright © 2008 Terms and Conditions