Clinical correlates of Developmental Anatomy

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Presentation transcript:

Clinical correlates of Developmental Anatomy

Gametogenesis Long prophase in oogenesis NON dis junction Abnormal gametes Abnormal Oocytes Abnormal Sperms

Spermatogenesis Aspermia Oligospermia Azoospermia

Contraception Contraceptive pills Intra Uterine devices Barrier contraceptives Surgical sterilization

Assisted reproductive techniques Dispermy and triploidy IVF Intracytoplasmic sperm injection Cryopreservation GIFT ZIFT Surrogate mothers

Fertilization & cleavage Non disjunction in early mitotic divisions of zygote Abnormal zygotes are usually missed

Ectopic implantation

Invasive Mole, Choriocarcinoma Hyadatidiform Mole Partial Dispermy Complete Dispermic fertilization Monospermic fertilization Invasive Mole, Choriocarcinoma

Basis of Pregnancy Test Syncitiotrophoblast secretes HCG Maintains corpous leuteum Basis for pregnancy test

Fate of primitive streak By end of 4th week diminishes Degenerates completely Sacrococygeal teratoma

Teratogenesis associated with gastrulation Chordoma Teratogenesis associated with gastrulation Highly sensitive stage Fate maps for major systems can be drawn

ABNORMALITIES Placenta Accreta. Placenta Percreta Placenta Previa Site of attachement of Umbilical cord Centre (usual) Battle dore: margin