Diagnosing the Pathophysiologic Mechanisms of Nocturnal Polyuria

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Diagnosing the Pathophysiologic Mechanisms of Nocturnal Polyuria An-Sofie Goessaert, Louise Krott, Piet Hoebeke, Johan Vande Walle, Karel Everaert European Urology Volume 67, Issue 2, Pages 283-288 (February 2015) DOI: 10.1016/j.eururo.2014.09.003 Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 1 Circadian rhythms for (A) diuresis rate, (B) free water clearance, (C) osmolality, (D) solute clearance, (E) sodium clearance, and (F) urea clearance for participants with and without nocturnal polyuria (NP) according to eight urine samples collected over 24h. Daytime urine samples were taken at 9–11 am (U1), 12–2 pm (U2), 3–5 pm (U3), 6–8 pm (U4), and 9–11 pm (U5). Nighttime urine samples were taken at 12–2 am (U6), 3–5 am (U7), and 6–8 am (U8). The table above each plot shows p values for the within-group Kruskall-Wallis test; values in italics are significant. Reversed rhythms are evident for all variables except urea clearance for the NP group compared to the reference group (p<0.05). *p<0.05 for NP versus the reference (no NP) group (Mann-Whitney U test). European Urology 2015 67, 283-288DOI: (10.1016/j.eururo.2014.09.003) Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 2 Distribution of the pathophysiologic mechanisms underlying nocturnal polyuria (NP) according to two different definitions: (A) NP index>20–33% and (B) nocturnal urine production>90ml/h. FWC=free water clearance. European Urology 2015 67, 283-288DOI: (10.1016/j.eururo.2014.09.003) Copyright © 2014 European Association of Urology Terms and Conditions