Exome Sequencing Followed by Large-Scale Genotyping Suggests a Limited Role for Moderately Rare Risk Factors of Strong Effect in Schizophrenia Anna C.

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Exome Sequencing Followed by Large-Scale Genotyping Suggests a Limited Role for Moderately Rare Risk Factors of Strong Effect in Schizophrenia Anna C. Need, Joseph P. McEvoy, Massimo Gennarelli, Erin L. Heinzen, Dongliang Ge, Jessica M. Maia, Kevin V. Shianna, Min He, Elizabeth T. Cirulli, Curtis E. Gumbs, Qian Zhao, C. Ryan Campbell, Linda Hong, Peter Rosenquist, Anu Putkonen, Tero Hallikainen, Eila Repo-Tiihonen, Jari Tiihonen, Deborah L. Levy, Herbert Y. Meltzer, David B. Goldstein The American Journal of Human Genetics Volume 91, Issue 2, Pages 303-312 (August 2012) DOI: 10.1016/j.ajhg.2012.06.018 Copyright © 2012 The American Society of Human Genetics Terms and Conditions

Figure 1 Range of Relative Risks and MAFs that Are Detectable with 99% Power at p < 0.05 and, after Correction for All Included Variants, p < 1.5 × 10−7 in a Cohort of 166 Cases and 307 Controls The American Journal of Human Genetics 2012 91, 303-312DOI: (10.1016/j.ajhg.2012.06.018) Copyright © 2012 The American Society of Human Genetics Terms and Conditions