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Methods Results Conclusions Protective Effect of Aloe vera Gel Extract Against Advers of Doxorubicin on Mice Ovary Sousan Lotfi, Mehri Azadbakht* Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran Lotfi.s1684@gmail.com, Azadbakht-tmu@yahoo.com Objectives Methods Results Doxorubicin (DOX) is one of the most important anticancer chemotherapy drugs that are used widely to treat solid tumors and leukemia (Chow et al,2010). The drug has side effects on most organs, including ovaries (Damani et al, 2002). Traditional medicine and the use of herbal medicines are today the most popular treatments. Aloe vera is one of the oldest medicinal plants that has high antioxidant properties (Langmead L, et al, 2004). We studied the protective effect of Aloe vera gel on adverse effects of Doxorubicin on mice ovary. female NMRI mice were divided into four groups. Doxorubicin group received DOX 3 mg/kg/wt intraperitoneally on days 7, 14, 21, and 28. Doxorubicin/Aloe vera group received DOX 3 mg/kg/wt intraperitoneally on days 7, 14, 21, and 28 and Aloe vera gel 200 mg/kg/wt daily for 28 days. Aloe vera group received Aloe vera gel 200 mg/kg/wt daily for 28 days and control group received nothing.after 28 days mice were sacrificed and removed the ovarys for tissue process. This process involves dehydration, clearing, embedding, molding and cutting with a microtom device with a thickness of 5 micrometers. Coloring was performed using Hematoxylin-Eosin staining method. Our results showed that Doxorubicin significantly decreased diameter of the ovary also the number of primary, prantral and antral follicles, and also significantly increased the number of atresia follicles compared to control group. But Aloe vera co-treated group showed significantly recovery in this parameters. Conclusions Therefore, Aloe vera gel can improve the damage caused by doxorubicin to the ovary and protect the ovary from the harmful effects of doxorubicin. Aloe vera/Dox Dox c/d: Significant different between groups (p<0.05).