Mouse Exercise Monitoring System Erik Lappinen, Brooks Alford, Elizabeth Smith, Matt Gallegly Advisors: Dr. Michael McDonald, Dr. Randall Reiserer Vanderbilt University Department of Biomedical Engineering

Objectives Project Description Background Requirements Hardware Software Timeline Budget

Project Description Large scale monitoring system for mice involved in pharmacological studies Display and record data from exercise wheel motion Possible to monitor up to 100 cages simultaneously

Project Background Exercise wheels provide wealth of information about mouse behavior and physiological changes Mouse testing accounts for 85-90% of all testing done in pharmaceuticals $400,000,000 development cost per drug in the U.S.

Project Requirements Required: Wish List: Monitor speed and distance Identify individual mice Real-time Store data for future analysis “Mouse Proof” Wish List: Monitor directionality of exercise wheel Addition of visual graphs of velocity and distance

Hardware Matched IR LED light source/photosensor pair Reflective surface placed on small portion of back side of mouse wheel surface

Hardware

Signal from Sensors Response for forward motion Response for reverse motion Sensor 2

Software Build off of existing LabView VI Continuously retrieves data from two digital input channels per cage

Software Digital Logic Gates Count Time between leading edges to measure RPM Clears after 5 seconds of inactivity

Timeline April 13 - Working Prototype April 20 - Continue Testing April 27 - Final Presentation

Budget TOTAL: ~ $1900 IR LED's: 100 @ $0.37 IR Detectors: 200 @ $0.28 CPU: 1 @ $936.00 Digital I/O Cards: 1 @ $145, 2 @ $391.50 Connector block/cable kit: 1 @ $63 Supplies for chassis (wood): ~$250 Wires, cables, etc: ~$100 Texts: 1 @ $70 TOTAL: ~ $1900