by Wendy Cozen, Dalin Li, Timothy Best, David J

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Presentation transcript:

A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32 by Wendy Cozen, Dalin Li, Timothy Best, David J. Van Den Berg, Pierre-Antoine Gourraud, Victoria K. Cortessis, Andrew D. Skol, Thomas M. Mack, Sally L. Glaser, Lawrence M. Weiss, Bharat N. Nathwani, Smita Bhatia, Fredrick R. Schumacher, Christopher K. Edlund, Amie E. Hwang, Susan L. Slager, Zachary S. Fredericksen, Louise C. Strong, Thomas M. Habermann, Brian K. Link, James R. Cerhan, Leslie L. Robison, David V. Conti, and Kenan Onel Blood Volume 119(2):469-475 January 12, 2012 ©2012 by American Society of Hematology

Results of a meta-analysis of 2 GWAS on 393 cases and 3315 controls. Results of a meta-analysis of 2 GWAS on 393 cases and 3315 controls. (A) Manhattan plot of the genome-wide results. P values were determined for each SNP based on the meta-analysis of the UC and USC samples. Five SNPs surpassed the genome-wide significance threshold (P value = 5 × 10−8): rs9268542, rs9268528, rs204999, rs2858870, and rs6903608 6p21.3. (B) Regional plot of the 6p21.3 for the combined genome-wide association results. The blue lines represent recombination rates. The previously reported SNP rs6903608 is designated by a diamond; all other SNPs are depicted by circles. (C) Linkage disequilibrium map of the 6p21.3 region (red represents r2 > 0.9). Wendy Cozen et al. Blood 2012;119:469-475 ©2012 by American Society of Hematology