Activation of PKC signaling reverses cell chirality in the myocardium before cardiac looping. Activation of PKC signaling reverses cell chirality in the.

Slides:

Advertisements

Similar presentations

ORL1 inhibits axon regeneration.

Advertisements

AF647-RIS is internalized by TAMs in vivo.

Identification and characterization of the ta2-1 mutant.

Altered cell migration factors and increased intestinal tumorigenesis in APC1638N/+ mice. Altered cell migration factors and increased intestinal tumorigenesis.

Chick cardiac cells before and during C looping exhibit dominant CW rotation in vitro. Chick cardiac cells before and during C looping exhibit dominant.

Decreased cell polarity and adhesion protein expression after 56Fe radiation. Decreased cell polarity and adhesion protein expression after 56Fe radiation.

Activation of PKC signaling reverses intrinsic chiral rotational bias of cardiac cells and reverses the directionality of cardiac looping. Activation of.

Polar angle mapping with DOT

Confocal microscope images of adult rat cerebellum, showing the distribution of GAD67 (immunolabeled with rhodamine: red) and Reelin mRNA (detected with.

Long-term decrease of IEC migration after 56Fe radiation relative to γ-rays. Long-term decrease of IEC migration after 56Fe radiation relative to γ-rays.

Impaired lymphatic valve protrusion in Tie2Cre;Piezo1cKO mice.

Klotho reduction causes macrophage invasion into the CP

CAFs enhance the acinar forming capacity of SOX2oe TUM622 cells and suppress dysplasia. CAFs enhance the acinar forming capacity of SOX2oe TUM622 cells.

TUM622 is capable of forming acinar-like structures in 3D ECM

Volume 6, Issue 5, Pages (May 2004)

Effect of dorsal rhizotomy on CaV2

Scanning electron microscopy analysis of EGK-I to -V chick embryos.

Ang II induces translocation of α-ENaC toward the apical membrane.

Mitofilin cluster distribution is denser in the perinuclear mitochondria. Mitofilin cluster distribution is denser in the perinuclear mitochondria. (A)

Transiently Reorganized Microtubules Are Essential for Zippering during Dorsal Closure in Drosophila melanogaster Ferenc Jankovics, Damian Brunner Developmental.

Direct fusion lines allow fluorescent visualization of plasmatocyte nuclei, the cytoplasm, or the cytoskeleton in embryos from stage (St) 8 onwards. Direct.

Immunologic responses after the MN-mediated cancer immunotherapy.

Rapid vimentin reorganisation upon BCR stimulation.

Mitofilin is localized in individual clusters in the mitochondria of primary adult human fibroblasts. Mitofilin is localized in individual clusters in.

STED microscopy of MINOS

Isaac Perea-Gil et al. BTS 2016;1:

Detection and tracking of individual SNAP-tagged proteins on the surface of living cells. Detection and tracking of individual SNAP-tagged proteins on.

CD169+ macrophages mediate Lm translocation to the splenic T cell zones. CD169+ macrophages mediate Lm translocation to the splenic T cell zones. (A) Confocal.

Volume 20, Issue 21, Pages (November 2010)

Nat. Rev. Neurol. doi: /nrneurol

The absence of the centrosome changes global microtubule dynamics in a migrating cell. The absence of the centrosome changes global microtubule dynamics.

Isaac Perea-Gil et al. BTS 2016;1:

Yuri Oleynikov, Robert H. Singer Current Biology

DMT1 expression in the mesencephalon of MPTP-intoxicated mice.

Differential secretion profiles of C. elegans TTR models.

Inhibition of ROCK activity rescues formation of polarized cysts in the absence of DDR1 signaling. Inhibition of ROCK activity rescues formation of polarized.

Imaging intracellular endosymbiont E. coli by fluorescent microscopy.

Numerical analysis of cell morphology of tapetal cells in wild type.

GFP+ cells derived from a passaged neurosphere implant contribute to peripheral nerves and DRG. (A) After the removal of an ∼1-mm section of spinal cord,

TSA causes premature chromatid sister separation.

Fig. 1. Representative images of the four cell lines using fluorescence microscopy. Representative images of the four cell lines using fluorescence microscopy.

Distribution and levels of phosphorylated PKC in L

Patterns of cell movement in paraxial mesoderm.

Fig. 1. Mitochondrial internalization in cardiomyocytes.

Indirect fluorescence assay of N. gruberi cells.

Fig. 3. Genetic interactions between unc-53 and unc-6 and between unc-53 and unc-5 affect intracellular UNC-40::GFP localization.(A–H) Photomicrographs.

Fig. 2. Ex vivo inducible knockout of PDCD2 in ESCs results in loss of S phase entry and increased p53.(A) Growth curve of inducible knockout and WT ESCs.

Aggresome formation of STAT5A_ΔE18.

High-affinity binding to the hypervariable region of the β1 I-like domain controls signaling to fibronectin fibrillogenesis. High-affinity binding to the.

ICAM-1 forms distinct complexes with filamin B, α-actinin-4 and cortactin. ICAM-1 forms distinct complexes with filamin B, α-actinin-4 and cortactin. (A)

Axial organisation of gastruloids.

High-affinity mutants of β3 integrin fail to stimulate RhoA activity and fibronectin fibrillogenesis. High-affinity mutants of β3 integrin fail to stimulate.

Fig. 2. Non-homogeneous subcellular distribution of Vangl2 along the anteroposterior axis. Non-homogeneous subcellular distribution of Vangl2 along the.

DNM inhibition affects ITGB1 activity and Rab11 cell distribution in human MKs. (A-B) Quantification of active ITGB1 at the surface of MKs. Representative.

Prophase nuclear movements in wild-type, rec8 and rec7 mutant cells.

The TAP population exhibits the highest mTORC1 signaling differences between dorsal and ventral regions. The TAP population exhibits the highest mTORC1.

Activation of glial cells.

Fibril-induced NM prions do not evolve from SGs.

Association of NM-HA and NM-GFP with SGs is transient.

Histone crotonylation in kidney tubular cells.

Temporal origins of h-ChCs labeled in Cdh6-CreER;Dlx5/6-Flp;Ai65 mice.

(A) Correlation between the shear modulus (Fig

Root initials and their early descendants are preferentially killed in response to DNA damage. Root initials and their early descendants are preferentially.

CLIC1 promotes tumor cell spreading through effects on MLCK

Binding and antiproliferative effects of ANG4043 and anti-HER2 mAbs on tumor cells. Binding and antiproliferative effects of ANG4043 and anti-HER2 mAbs.

CLIC1 is upregulated in invadopodia of fibrin-embedded tumor and endothelial cells. CLIC1 is upregulated in invadopodia of fibrin-embedded tumor and endothelial.

Fig. 5 C9orf72 knockdown disrupts autophagy induction.

CDC-42 controls early cell polarity and spindle orientation in C

Fig. 1 Schematic structure of a fluorescently labeled eGLP1-conjugated MALAT1 ASO and internalization of fluorescent eGLP1 and eGLP1-MALAT1-ASO. Schematic.

The neuropod cells. The neuropod cells. (Top left) Neuropod cells synapse with sensory neurons in the small intestine, as shown in a confocal microscopy.

Presentation transcript:

Activation of PKC signaling reverses cell chirality in the myocardium before cardiac looping. Activation of PKC signaling reverses cell chirality in the myocardium before cardiac looping. (A) Confocal images of Golgi (anti-GM130, green) and nucleus (Hoechst, blue) in the ventral myocardium of control and TPA (a PKC activator)-treated embryos at HH9. (B) Circular histogram of angle distribution of Golgi polarization in the ventral myocardium at HH9 in control and TPA-treated groups. n = (number of cells, number of embryos). (C) Quantification of Golgi polarization with respect to the nucleus along the anterior–posterior and right–left axes for control and TPA-treated embryos. (D) Confocal images of the chick ventral myocardium at HH9 for control and TPA-treated chicken embryos, with Phalloidin (F-actin) staining to visualize cell boundaries. (E) Circular histogram of angle distribution of cell boundaries in the ventral myocardium at HH9 for control and TPA-treated embryos. n = (number of cell boundaries, number of embryos). (F) Percentage of cell boundaries in the ventral myocardium at HH9 with angles between −90° to 0° and 0°–90° for control and TPA-treated embryos. **P < 0.01, ***P < 0.001. A, anterior; L, left; P, posterior; R, right. (Scale bars: 20 µm.)‏ Poulomi Ray et al. PNAS doi:10.1073/pnas.1808052115 ©2018 by National Academy of Sciences