A CRTCal Link between Energy and Life Span Anne Brunet  Cell Metabolism  Volume 13, Issue 4, Pages 358-360 (April 2011) DOI: 10.1016/j.cmet.2011.03.012 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 The CRTC-1/CREB Module Functions Downstream of AMPK and Calcineurin to Regulate Life Span in Worms (A) In the presence of high nutrients, AMPK is inactivated whereas calcineurin is activated. CRTC-1 is dephosphorylated and translocates into the nucleus, where it binds to CREB to upregulate CREB-dependent target gene expression. (B) Low nutrients activate AMPK. Activated AMPK directly phosphorylates CRTC-1 at two conserved sites, resulting in 14-3-3 binding and CRTC-1 sequestration in the cytoplasm. The inactivation of the CRTC-1/CREB module elicits the indirect upregulation of ER stress genes, which may contribute to life span extension. Cell Metabolism 2011 13, 358-360DOI: (10.1016/j.cmet.2011.03.012) Copyright © 2011 Elsevier Inc. Terms and Conditions