Novel Patch for Transdermal Administration of Morphine

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Presentation transcript:

Novel Patch for Transdermal Administration of Morphine Naoki Inui, MD, PhD, Tatsuhisa Kato, PhD, Shinya Uchida, PhD, Kingo Chida, MD, PhD, Kazuhiko Takeuchi, MD, PhD, Takahito Kimura, PhD, Hiroshi Watanabe, MD, PhD Journal of Pain and Symptom Management Volume 44, Issue 4, Pages 479-485 (October 2012) DOI: 10.1016/j.jpainsymman.2011.10.022 Copyright © 2012 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Illustration of the new transdermal morphine hydrochloride patch. The patch consists of a nonwoven fabric, polyethylene sponge foam as a retaining agent, and an adhesive film to attach the patch to the dermal surface. The polyethylene sponge foam is impregnated with morphine hydrochloride. Journal of Pain and Symptom Management 2012 44, 479-485DOI: (10.1016/j.jpainsymman.2011.10.022) Copyright © 2012 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Plasma concentration-time curves of a) morphine and its metabolites, b) morphine-3-glucuronide, and c) morphine-6-glucuronide, after transdermal administration of morphine. Data represent means±SEs. The levels increase in a time-dependent manner after morphine hydrochloride patch application. After detachment of the patches, the plasma levels of morphine decrease gradually. Journal of Pain and Symptom Management 2012 44, 479-485DOI: (10.1016/j.jpainsymman.2011.10.022) Copyright © 2012 U.S. Cancer Pain Relief Committee Terms and Conditions