Antibody–mediated C5 inhibition in hepatocyte-Cfh−/− mice during accelerated serum NTN. (A) Hematuria, (B) serum urea, (C) red cell fragments, (D) glomerular.

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Antibody–mediated C5 inhibition in hepatocyte-Cfh−/− mice during accelerated serum NTN. (A) Hematuria, (B) serum urea, (C) red cell fragments, (D) glomerular thrombosis score, and (E) glomerular neutrophil numbers at day 4 after administration of NTS to pre... Antibody–mediated C5 inhibition in hepatocyte-Cfh−/− mice during accelerated serum NTN. (A) Hematuria, (B) serum urea, (C) red cell fragments, (D) glomerular thrombosis score, and (E) glomerular neutrophil numbers at day 4 after administration of NTS to preimmunized hepatocyte-Cfh−/− mice treated with either BB5.1 (n=11) or isotype-matched antibody (n=10). Horizontal bars denote median values. P values were derived from Mann–Whitney test. RBC, red blood cell. Katherine A. Vernon et al. JASN 2016;27:1334-1342 ©2016 by American Society of Nephrology