Effect of intervention on participant serum 25OHD concentration and total symptom severity (A). Effect of intervention on participant serum 25OHD concentration.

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Effect of intervention on participant serum 25OHD concentration and total symptom severity (A). Effect of intervention on participant serum 25OHD concentration and total symptom severity (A). Box plot serum 25OHD concentrations (ng/mL) before and after intervention with placebo, vitamin D3 or vitamin D3+Probiotic (all participants), a significantly greater increase with vitamin D supplementation alone or with probiotic was seen over placebo group (B). Repeated measure of total symptom severity against time point (all participants) (C). Box plot serum 25OHD concentrations (ng/mL) before and after intervention with placebo, vitamin D3 or vitamin D3+Probiotic. (deplete participants only), a significant increase in serum 25OHD was seen in all groups with a greater response associated with vitamin D supplementation alone or with probiotic when compared to placebo group (D). Repeated measure of total symptom severity against time point (deplete participants only). Simon Tazzyman et al. BMJ Open Gastroenterol 2015;2:e000052 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/