Updates in Migraine From a 2018 American Headache Meeting

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Presentation transcript:

Updates in Migraine From a 2018 American Headache Meeting

This program will include a discussion of off-label treatments, devices, and investigational agents not approved by the FDA for use in the United States, and the data were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.

Acute Treatment of Migraine

Use of Acute Rx Treatments Among CaMEO Study Participants

MAST Study of Unmet Needs in Migraine

RDBPC, Phase 3, Trials of Lasmiditan: SAMURAI and SPARTAN

Dizziness in SAMURAI and SPARTAN

Sumatriptan and Lasmiditan Inhibit KCl-Induced CGRP release

Multicenter, RDBPC, Phase 3, Single-Attack Trial of Ubrogepant

Ubrogepant in Adults With Migraine: Results

Phase 3, RDBPC, Trial of Rimegepant in Adults With Migraine: Study Design

Rimegepant in Adults With Migraine: Results

Sumatriptan vs Rimegepant vs BHV-3500

Prevention of Migraine

Prevention of Migraine: FDA Status of mAbs

RDBPC 12-Week Trial of Fremanezumab for Preventative Treatment of EM: Onset of Efficacy

Rapid Onset of Galcanezumab for the Prevention of EM: EVOLVE-1 and EVOLVE-2

Onset of Efficacy in Phase 3 PROMISE-2 CM Trial

Reversion of CM to EM With CGRP-Targeted mAbs

Post-hoc Analysis of RDBPC Phase 3 Trial of Erenumab in CM: Conversion to EM

Post-hoc Analysis of RDBPC Phase 3 Trial of Fremanezumab in CM: Reversion of EM

The Prevention of Migraine With CGRP-Targeted mAbs: Long-Term Results

Long-Term Data With Erenumab in CM

Treatment of EM and CM Response Over Time With Fremanezumab

The Efficacy of CGRP-Targeted mAbs in Previous Treatment Failure

Galcanezumab After Treatment Failure to OnabotulinumtoxinA in Patients With Migraine

EVOLVE-1, EVOLVE-2, and REGAIN: Galcanezumab in Patients Who Failed to Respond to Preventive Treatments

EVOLVE-1, EVOLVE-2, and REGAIN: Galcanezumab in Patients Who Failed to Respond to Preventive Treatments (cont)

EVOLVE-1, EVOLVE-2, and REGAIN: Galcanezumab in Patients Who Failed to Respond to Preventive Treatments (cont)

Multicenter RDBPC Phase 3a Liberty Trial of Erenumab: Response in Patients With Preventive Treatment Failures

Wolff Award Lecture

Endotypes of Migraine Derived From CaMEO Data

Abbreviations

Abbreviations (cont)