HDAC3 silencing promotes nonamyloidogenic APP processing and decreases Aβ1–42:Aβ1–40 ratio. HDAC3 silencing promotes nonamyloidogenic APP processing and.

Slides:



Advertisements
Similar presentations
Fig. 1 Anti-inflammatory drug treatment reduces the number of reactive microglia in the hippocampus of APPV717I mice. APPV717I transgenic mice (10 months.
Advertisements

A B C D Supplementary Figure 1 CMV p300
IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.
Comparison (θ) of the mean dinucleotide variability distribution for (A) genes with MAE vs. Comparison (θ) of the mean dinucleotide variability distribution.
Comparison (R) of the mean observed to expected dinucleotide distribution for (A) genes with MAE vs. Comparison (R) of the mean observed to expected dinucleotide.
(A) Schematic illustration of the experimental design for the analysis of the RNase activity of MARF1 in oocytes by mutating the conserved D272 residue.
Body weight at harvest (g) Left kidney:body weight ratio (g/kg)
(A) Heat map showing expression changes during in vitro differentiation of nscs to astrocytes. (A) Heat map showing expression changes during in vitro.
Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25 cells. Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25.
CatL activity levels and expression of the DC forms of CatB and CatL are reduced in the α5β1-negative CHO cells. CatL activity levels and expression of.
Altered cell migration factors and increased intestinal tumorigenesis in APC1638N/+ mice. Altered cell migration factors and increased intestinal tumorigenesis.
Decreased cell polarity and adhesion protein expression after 56Fe radiation. Decreased cell polarity and adhesion protein expression after 56Fe radiation.
Trx80 is generated by α‐secretases. A
Cell-type–specific ERV expression in primary cells.
HDAC3, but not HDAC2 is in complex with tau protein.
Repeated administration of RGFP-966 improves short-term recognition and spatial memory in 3xTg-AD mice. Repeated administration of RGFP-966 improves short-term.
In vivo selectivity of compound 6b.
Acetylation Unleashes Protein Demons of Dementia
Pretreatment of VSV-GPΔ to form VSV-GP19K rescues infection in the α5β1-integrin-negative CHO cells. Pretreatment of VSV-GPΔ to form VSV-GP19K rescues.
REV-ERBα agonists reduce protein O-GlcNAcylation.
RGFP-966 decreases HDAC3 activity and is not cytotoxic.
Motor coordination is enhanced by genetic deletion of Best1 or MAOB but impaired by overexpression of MAOB. (A) Experimental timeline and schematic illustration.
Heavy-ion radiation decreases expression of key cellular tight junction proteins and alters microtubule dynamics in mouse intestine. Heavy-ion radiation.
Klotho reduction in CP primes hippocampal microglia for activation.
Long-term up-regulation of proliferative markers and down-regulation of cell migration factors along with increased intestinal metaplasia after 56Fe radiation.
Transcriptional response to mating in whole A. gambiae females.
Analysis of hESC stages of pluripotency.
RGFP-966 increases H4K12 acetylation in HEK/APPsw cells.
STED microscopy of MINOS
Atp1a3 phosphomutants show alterations in subcellular localization.
Volume 1, Issue 6, Pages (December 2013)
Expression of NCoR1∆ID in PAX8−/− mice does not reverse repression of T3-positive target genes. qPCR on the indicated pituitary (A) and neuronal (B) genes.
Nat. Rev. Neurol. doi: /nrneurol
Sleep/wake phenotype of S551D mutant mice.
Supriya Kapas, Paula M. Farthing  Journal of Investigative Dermatology 
Fig. 1 BX795 suppresses HSV-1 infection.
Histamine Inhibits the Production of Interferon-induced Protein of 10 kDa in Human Squamous Cell Carcinoma and Melanoma  Naoko Kanda, Shinichi Watanabe 
Mixed mutant biofilms have restoration of extracellular matrix structure and function. Mixed mutant biofilms have restoration of extracellular matrix structure.
Figure 5 ADP-induced inflammatory responses require P2Y12 receptors in human microgliaIncreasing concentrations of ADP (5, 50, and 200 μM) increased tumor.
Expression of PITPNM3 in cultured FLS and the stimulatory effect of CCL18. Expression of PITPNM3 in cultured FLS and the stimulatory effect of CCL18. Expression.
Treatment of dogs with celecoxib interferes with the effect of low-dose aspirin on ex vivo platelet aggregation. Treatment of dogs with celecoxib interferes.
CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair depigmentation CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair.
CKL family is involved in the circadian clock.
Supplementary Figure 5: Effect of S48168 on normalized organ and skeletal muscle weights after 12 weeks of treatment for all the experimental groups from.
Figure 2 SORL1 mutants' overexpression increases β-amyloid secretion
Pi and FGF2 differentially activate the FGFR1-FRS2α-ERK pathway.
The up-regulation of Galnt3 by Pi requires activation of the ERK pathway and induction of Egr1 and Etv5. The up-regulation of Galnt3 by Pi requires activation.
BHLH1a localizes in the nucleus, and its overexpression alters rhythmic diel gene expression. bHLH1a localizes in the nucleus, and its overexpression alters.
Effect of insulin on hepcidin expression in HepG2 cells.
Quantification of TBS-, FA-soluble Aβ40/42, and Aβ oligomers in the brain of adult and aged APP/PSEN1 and APP/PSEN1/APOEnull mice. Quantification of TBS-,
TOR, but not OSP, blocks STx2B transport and alters endosomal dynamics
Volume 19, Issue 10, Pages (June 2017)
Class II HDACs are functionally redundant, but HDAC5 is the primary GLUT4 regulator in 3T3-L1 preadipocytes. Class II HDACs are functionally redundant,
Naoko Kanda, Shinichi Watanabe  Journal of Investigative Dermatology 
Effect of FGF8 on R-C marker expression.
CPPED1 (A) and PPARγ2 (B) mRNA expressions in cultured SGBS cells during adipocyte differentiation. CPPED1 (A) and PPARγ2 (B) mRNA expressions in cultured.
Npas4 is a stress-induced factor in pancreatic β-cells.
Effect of PPARγ agonist on Aβ phagocytosis in primary microglia.
Peripheral surgery regulates expression of astrocytic markers.
The developmental spine morphology changes predict decreased biochemical compartmentalization with age, while loss of FMRP subtly influences this in an.
APP processing and the formation of Aβ peptide.
FMRP S499 rephosphorylation kinetics after CX-4945 treatment and washout mirrors a known CK2 target. FMRP S499 rephosphorylation kinetics after CX-4945.
FMRP S499 is phosphorylated by multiple kinases in vitro.
Trametinib and combination promote moDC maturation and decrease moDC viability. Trametinib and combination promote moDC maturation and decrease moDC viability.
Fig. 5 C9orf72 knockdown disrupts autophagy induction.
AR inhibition decreases ER+/AR+ breast cancer growth.
Hcy decreases VEGFR1/2 and Angs (Ang1, Ang2) gene transcription
Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105. Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105.
Expansion of omental FRCs and FALC remodeling after intraperitoneal exposure to bacterial antigen. Expansion of omental FRCs and FALC remodeling after.
Alp1 induces ASM contraction.
Presentation transcript:

HDAC3 silencing promotes nonamyloidogenic APP processing and decreases Aβ1–42:Aβ1–40 ratio. HDAC3 silencing promotes nonamyloidogenic APP processing and decreases Aβ1–42:Aβ1–40 ratio. (A) 10 μM RGFP-966 increases expression of sAPPα and (B) cellular APP in HEK/APPsw. Immunoblots showing increase of (C) sAPPα and (D) cellular APP in response to 10 μM RGFP-966 in HEK/APPsw whole-cell extract. (E and F) 10 μM HDAC3 RGFP-966 decreased the expression of β-secretase components (BACE1 and BACE2). Lower concentrations of RGFP-966 did not influence BACE1 or BACE2 expression. (G) RGFP-966 decreased expression of secreted sAPPβ at 10 μM, while (H) decreasing neurotoxic secreted Aβ1–42 and increasing nontoxic secreted Aβ1–40 in a dose-dependent manner 48 h after treatment. Yellow indicates neuroprotective APP metabolites. Dark orange indicates APP metabolites and transcripts known to be pathogenic. One-way ANOVA with Dunnett’s multiple-comparisons test was used. The graphs represent mean ± SEM. **P < 0.01, ****P < 0.001; n = 4–7. Karolina J. Janczura et al. PNAS 2018;115:47:E11148-E11157 ©2018 by National Academy of Sciences