Support with intra-aortic balloon pump vs. Impella2

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Ole K. Møller-Helgestad 1 In collaboration with CB Poulsen, MD 2 EH Christiansen, MD, PhD 2 JF Lassen, MD, PhD 2 HB Ravn, MD, PhD, DMSc 1 1: Dept. of.

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Support with intra-aortic balloon pump vs. Impella2 Support with intra-aortic balloon pump vs. Impella2.5® and blood flow to the heart, brain and kidneys — An experimental porcine model of ischaemic heart failure Ole K. Møller-Helgestad, Christian B. Poulsen, Evald H. Christiansen, Jens F. Lassen, Hanne B. Ravn International Journal of Cardiology Volume 178, Pages 153-158 (January 2015) DOI: 10.1016/j.ijcard.2014.10.153 Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Timeline of events. Measurements are performed at designated timepoints outlined as white, light grey, dark grey and black bars on the graph. White indicates no mechanical support, light grey Impella®-support, black IABP-support and dark grey indicates combined support. The dotted bar indicates Impella operating at 1L/min to support the pig during ischaemia and reperfusion. * Time of randomisation. The solid line indicates 45min of ischaemia followed by 30min of reperfusion (dotted line). International Journal of Cardiology 2015 178, 153-158DOI: (10.1016/j.ijcard.2014.10.153) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Carotid blood flow as columns indicating mean values in mL/min according to the support device with error bars indicating the standard deviation. Analysed by matched one-way ANOVA with Dunnett's multiple comparison test. Significant differences from the no-support 10min stage are highlighted. Baseline n=13, the other stages n=11. International Journal of Cardiology 2015 178, 153-158DOI: (10.1016/j.ijcard.2014.10.153) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Renal blood flow as columns indicating mean values in mL/min according to the support device with error bars indicating the standard deviation. Analysed by matched one-way ANOVA with Dunnett's multiple comparison test. Significant difference from the no-support 10min is highlighted. Baseline n=10, the other stages n=8. International Journal of Cardiology 2015 178, 153-158DOI: (10.1016/j.ijcard.2014.10.153) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Left Anterior Descending Blood Flow as columns indicating mean values in mL/min according to the support device with error bars indicating the standard deviation. Analysed by matched one-way ANOVA with Dunnett's multiple comparison test. Baseline n=8, the other stages n=7. International Journal of Cardiology 2015 178, 153-158DOI: (10.1016/j.ijcard.2014.10.153) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions