Michael S. Schieber, Navdeep S. Chandel Cancer Cell

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ROS Links Glucose Metabolism to Breast Cancer Stem Cell and EMT Phenotype Michael S. Schieber, Navdeep S. Chandel Cancer Cell Volume 23, Issue 3, Pages 265-267 (March 2013) DOI: 10.1016/j.ccr.2013.02.021 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Epigenetic Silencing of FBP1 Decreases ROS to Promote CSC and EMT Phenotype in BLBC FBP1 coverts F-1,6,-BP to F-6P in the rate-limiting step of gluconeogenesis (right). Epigenetic silencing of FBP1, through promoter methylation by the Snail-G9a-Dnmt1 complex, promotes glycolytic flux. An increased reliance on glucose metabolism following FBP1 silencing lowers ROS levels by two mechanisms: decreased mitochondrial respiration and increased NADPH synthesis through pentose phosphate metabolism. Lower ROS levels promote EMT and CSC phenotype in BLBC. Cancer Cell 2013 23, 265-267DOI: (10.1016/j.ccr.2013.02.021) Copyright © 2013 Elsevier Inc. Terms and Conditions