Suppression of tonic inhibition by genetic deletion of Best1 and enhancement by overexpression of MAOB. (A) Schematic illustration for tonic current recording.

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Suppression of tonic inhibition by genetic deletion of Best1 and enhancement by overexpression of MAOB. (A) Schematic illustration for tonic current recording in cerebellar GCs by whole-cell patch clamp. Suppression of tonic inhibition by genetic deletion of Best1 and enhancement by overexpression of MAOB. (A) Schematic illustration for tonic current recording in cerebellar GCs by whole-cell patch clamp. (B, C, E, and F) Representative traces of tonic current in cerebellar GCs from WT mice (B and E) and Best1 KO mice (Balb/C strain) (C and F). +GABA indicates the adding of 5 μM GABA in the recording solution. (D and G) The magnitude of 50-μM GABAzine-sensitive tonic current as indicated (unpaired t test). (H) Schematic showing doxycycline (Dox)-dependent MAOB overexpression in astrocytes. (I, J, L, and M) Representative traces of tonic current from GFAP-MAOB mice (C57BL/6 strain) in −Dox (I and L) and +Dox (J and M) conditions. +GABA indicates the adding of 5 μM GABA in the recording solution. (K and N) The magnitude of GABAzine-sensitive tonic current as indicated (unpaired t test). Error bars are SEM; *P < 0.05; ***P < 0.001; ns indicates P > 0.05. BG, Bergmann glia; GBZ, GABAzine; GCL, GC layer; IHC, immunohistochemistry; MF, mossy fiber; ML, molecular layer; PCL, PC layer; Rec., recording pipette; rtTA, reverse tetracycline responsive transactivator; TET, tetracycline-responsive promoter. Junsung Woo et al. PNAS 2018;115:19:5004-5009 ©2018 by National Academy of Sciences