Challenges in Translational Research TRANSLATIONAL BLOCKS Lack of participants Career disincentives Regulatory burden Practice limitations Lack of infrastructure High research costs Need for databases Need for qualified investigators Clinical Reseach Continuum Sung, N. S. et al. JAMA, 2003

Needs of the Translational Researcher Experienced site of practice REMOVE THE ROADBLOCKS Assistance in research oversight Education and training Novel laboratory support and product development Assistance in protocol development and biostatistics

Utilize All Resources (it takes a village to raise a translational researcher) Cores and facilities e.g. gene array, transgenic, pathology Recruitment tools Workshops Research Centers www.crc.washington.edu

General Clinical Research Center Funded by a grant from NIH; National Center for Research Resources One of 78 centers around the US UW GCRC in existence for 44 years Provides clinical research support to investigators

Research Subject Advocate Program Cell and Gene Therapy Core Bionutrition Core Pediatric Clinical Care Unit Adult Clinical Care Unit Administrative Core Education and Biostatistical Core Informatics Core Therapeutics Development Network