Martina Semenzato, Sara Cogliati, Luca Scorrano Chemistry & Biology

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Prohibitin(g) Cancer: Aurilide and Killing by Opa1-Dependent Cristae Remodeling Martina Semenzato, Sara Cogliati, Luca Scorrano Chemistry & Biology Volume 18, Issue 1, Pages 8-9 (January 2011) DOI: 10.1016/j.chembiol.2011.01.001 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 Molecular Mechanisms of Action of Proapoptotic Mitochondrial Drugs: BH3 Mimetics and Aurilide While BH3 mimetics lead to outer membrane permeabilization by acting on the Bcl-2 rheostat, aurilide shows a new mechanism by acting on the Phb/Opa1-dependent cristae remodeling pathway. Key molecular players are defined in the legend. OM, outer membrane; IBM, inner boundary membrane; CJ, cristae junction; IMS-Opa1, soluble Opa1; IM-Opa1, membrane integral Opa1. Chemistry & Biology 2011 18, 8-9DOI: (10.1016/j.chembiol.2011.01.001) Copyright © 2011 Elsevier Ltd Terms and Conditions