Should chloride-rich crystalloids remain the mainstay of fluid resuscitation to prevent ‘pre-renal’ acute kidney injury?: con Dileep N. Lobo, Sherif.

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Should chloride-rich crystalloids remain the mainstay of fluid resuscitation to prevent ‘pre-renal’ acute kidney injury?: con Dileep N. Lobo, Sherif Awad Kidney International Volume 86, Issue 6, Pages 1096-1105 (December 2014) DOI: 10.1038/ki.2014.105 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Rationale for fluid resuscitation to prevent acute kidney injury. Kidney International 2014 86, 1096-1105DOI: (10.1038/ki.2014.105) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Schematic diagram of the sequential effects of hyperchloremia on the kidney. Numbers indicate the sequence of events. A1-receptor, adenosine1-receptor. Kidney International 2014 86, 1096-1105DOI: (10.1038/ki.2014.105) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 3 Adverse events related to intravenous therapy with 0.9% saline when compared with balanced crystalloids. The evidence has been collected from animal studies, healthy volunteer studies, small randomized clinical trials, and large patient cohort studies, and cannot be presently regarded as Grade A. Kidney International 2014 86, 1096-1105DOI: (10.1038/ki.2014.105) Copyright © 2014 International Society of Nephrology Terms and Conditions